Adolescent fiber intake and mammographic breast density in premenopausal women.
Adolescent fiber intake and mammographic breast density in premenopausal women.
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DOI：
10.1186/s13058-016-0747-8
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发表时间：
2016-08-12
期刊：
影响因子：
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通讯作者：
Tamimi RM
中科院分区：
文献类型：
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作者：
Yaghjyan L;Ghita GL;Rosner B;Farvid M;Bertrand KA;Tamimi RM
到目前为止，青少年饮食与乳房X线摄影乳腺密度（乳腺癌的一个强有力的和一致的预测因素）之间的关联的流行病学证据有限且不一致。我们调查了青春期纤维摄入量与绝经前妇女乳腺摄影密度的关系。这项研究包括743名无癌症的绝经前妇女（平均年龄44.9岁）的护士健康研究II队列。使用计算机辅助阈值技术，从数字化乳腺X线摄影测量乳腺密度百分比、绝对密度和非密度区域。青少年和成人的饮食进行了评估，食物频率问卷，能量调整的营养摄入量估计每种食物。有关乳腺癌风险因素的信息来自基线或最接近乳房X线检查日期的两年期问卷调查。我们使用广义线性回归来量化青少年纤维摄入量的四分位数与每种乳腺密度测量值之间的关联，并对潜在的混杂因素进行了调整。分别检查了总纤维摄入量的关联;来自水果，蔬菜，豆类和谷物的纤维;以及纤维的食物来源（水果，蔬菜和坚果）。在多变量分析中，青春期的总纤维摄入量与乳腺密度百分比（趋势p = 0.64）、绝对致密面积（趋势p = 0.80）或非致密面积（趋势p = 0.75）无关。同样，青春期摄入水果、蔬菜、豆类或谷物纤维或特定来源的纤维（水果、蔬菜或坚果）与任何乳房摄影密度表型都无关。我们的研究结果并不支持青少年纤维摄入量与绝经前乳房X线摄影乳腺密度相关的假设。
To date, there is limited and inconsistent epidemiologic evidence for associations of adolescent diet with mammographic breast density, a strong and consistent predictor of breast cancer. We investigated the association of adolescent fiber intake with mammographic density in premenopausal women. This study included 743 cancer-free premenopausal women (mean age, 44.9 years) within the Nurses’ Health Study II cohort. Percent breast density, absolute dense and non-dense areas were measured from digitized film mammograms using a computer-assisted thresholding technique. Adolescent and adult diet were assessed with a food frequency questionnaire; energy-adjusted nutrient intakes were estimated for each food item. Information regarding breast cancer risk factors was obtained from baseline or biennial questionnaires closest to the mammogram date. We used generalized linear regression to quantify associations between quartiles of adolescent fiber intake and each of the breast density measures, adjusted for potential confounders. Associations were examined separately for total fiber intake; fiber from fruits, vegetables, legumes, and cereal; and food sources of fiber (fruits, vegetables, and nuts). In multivariable analyses, total fiber intake during adolescence was not associated with percent breast density (p for trend = 0.64), absolute dense area (p for trend = 0.80), or non-dense area (p for trend = 0.75). Similarly, neither consumption of fiber from fruits, vegetables, legumes, or cereal nor specific sources of fiber intake (fruits, vegetables, or nuts) during adolescence were associated with any of the mammographic density phenotypes. Our findings do not support the hypothesis that adolescent fiber intake is associated with premenopausal mammographic breast density.