The effect of life-history and mode of inheritance on neutral genetic variability
The effect of life-history and mode of inheritance on neutral genetic variability
复制标题
DOI：
10.1017/s0016672301004979
复制
发表时间：
2001-04-01
影响因子：
1.5
通讯作者：
Charlesworth, B
中科院分区：
文献类型：
--
作者：
Charlesworth, B
常染色体染色体的有效种群大小公式。在年龄结构人群中开发了x连锁、y连锁和母系遗传位点。这里使用的近似值既可以预测同一性概率的渐近增长率，也可以预测无限位点模型下中性核苷酸位点多样性的平衡水平。讨论了该结果在果蝇、植物和人类种群DNA序列变异数据解释中的应用。结论是，人口统计学参数（如成人死亡率）的性别差异通常对不同遗传模式的基因座的相对有效种群大小影响不大，而生殖成功差异的性别差异可能产生重大影响，相对于常染色体或y染色体基因座，x连锁基因座的有效种群大小可能增加或减少。当试图理解具有不同传播模式的基因序列变异模式的数据时，需要考虑这些影响。
Formulae for the effective population sizes of autosomal. X-linked, Y-linked and maternally transmitted loci in age-structured populations are developed. The approximations used here predict both asymptotic rates of increase in probabilities of identity, and equilibrium levels of neutral nucleotide site diversity under the infinite-sites model. The applications of the results to the interpretation of data on DNA sequence variation in Drosophila, plant, and human populations are discussed. It is concluded that sex differences in demographic parameters such as adult mortality rates generally have small effects on the relative effective population sizes of loci with different modes of inheritance, whereas differences between the sexes in variance in reproductive success can have major effects, either increasing or reducing the effective population size for X-linked loci relative to autosomal or Y-linked loci. These effects need to be accounted for when trying to understand data on patterns of sequence variation for genes with different transmission modes.