Filifactor alocis brain abscess identified by 16S ribosomal RNA gene sequencing: A case report
Filifactor alocis brain abscess identified by 16S ribosomal RNA gene sequencing: A case report
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DOI：
10.1016/j.jiac.2019.09.013
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发表时间：
2020-02-01
影响因子：
2.2
通讯作者：
Mikasa, Keiichi
中科院分区：
文献类型：
--
作者：
Hishiya, Naokuni;Uno, Kenji;Mikasa, Keiichi
我们报告一位85岁的男性，在一周前有蛀牙，发生了Filifactoralocis脑脓肿。在这种情况下，脓肿手术引流后，经验性抗生素已开始。虽然病原菌不能通过培养鉴定，但F。通过从脓肿中分离的脓液的16S核糖体RNA（16S rRNA）基因测序检测alocis。经手术引流和长期抗生素治疗（包括甲硝唑、头孢曲松和美罗培南8周）后，患者恢复，无严重后遗症。在这种情况下的研究结果强调，16S rRNA基因测序允许细菌诊断脑脓肿时，表型鉴定失败，如在病人正在接受抗菌治疗的情况下，在采样时，或在病人感染了苛养微生物。(c)2019年日本化疗学会和日本传染病协会。由爱思唯尔有限公司出版。保留所有权利。
We report a clinical case of Filifactor alocis brain abscess in an 85-year-old man who had decayed teeth 1 week prior. In this case, the abscess was surgically drained after empirical antibiotics had been initiated. Although the causative organism could not be identified by culture, F. alocis was detected via 16S ribosomal RNA (16S rRNA) gene sequencing of the pus isolated from the abscess. The patient recovered without serious sequelae after surgical drainage and prolonged antibiotic treatment, including metronidazole, ceftriaxone and meropenem for 8 weeks. The findings in this case emphasize that 16S rRNA gene sequencing allows bacterial diagnosis of brain abscess when phenotypic identification fails, such as in cases where patients are undergoing antimicrobial treatment at the time of sampling or where patients are infected with fastidious organisms. (c) 2019 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.