Glutathione-Mediated Clearable Nanoparticles Based on Ultrasmall Gd2O3 for MSOT/CT/MR Imaging Guided Photothermal/Radio Combination Cancer Therapy
Glutathione-Mediated Clearable Nanoparticles Based on Ultrasmall Gd2O3 for MSOT/CT/MR Imaging Guided Photothermal/Radio Combination Cancer Therapy
复制标题
基于超小 Gd2O3 的谷胱甘肽介导的可清除纳米颗粒，用于 MSOT/CT/MR 成像引导光热/无线电组合癌症治疗
DOI：
10.1021/acs.molpharmaceut.9b00332
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发表时间：
2019-08-01
影响因子：
4.9
通讯作者：
Li, Nan
中科院分区：
文献类型：
--
作者：
Cheng, Yu;Lu, Tong;Li, Nan
近年来，多功能可清除的无机治疗诊断纳米粒子受到越来越多的关注。蛋白质基纳米颗粒可被肝胆系统有效清除。在这项工作中，超小的氧化钆（Gd 2 O3）纳米粒子，具有高的纵向弛豫速率的优势，与牛血清白蛋白（BSA）的包裹。将Gd 2 O3/BSA纳米粒子与二维光热MoS 2纳米材料连接后，通过二硫键修饰透明质酸（HA），实现肿瘤靶向性。体外和体内研究表明，这些Gd 2 O3/BSA@MoS2-HA纳米颗粒可以通过氧化还原反应与谷胱甘肽（GSH）反应后迅速降解并排出体外，从而避免了长期毒性。此外，细胞摄取研究和体内多光谱光声断层扫描（MSOT），X射线计算机断层扫描（CT）和磁共振（MR）三模态图像表明，静脉注射后，Gd 2 O3/BSA@MoS2-HA纳米颗粒表现出高肿瘤摄取效应。因此，这种可清除的治疗诊断纳米粒子具有多种功能，这是适用于多模式成像引导的癌症治疗，可能会显示出在纳米医学科学的应用前景。
Recently, multifunctional clearable inorganic theranostic nanoparticles have been attracting more and more attention. Protein-based nanoparticles can be cleared by the hepatobiliary system efficiently. In this work, ultrasmall gadolinium oxide (Gd2O3) nanoparticles, which possess the advantage of high longitudinal relaxation rate, were coated with bovine serum albumin (BSA). After the Gd2O3/BSA nanoparticles were linked with two-dimensional photothermal MoS2 nanomaterials, the nanoparticles were also modified with hyaluronic acid (HA) through the disulfide bonds for tumor-targeting effect. As indicated by in vitro and in vivo studies, these Gd2O3/BSA@MoS2-HA nanoparticles could be rapidly degraded and excreted after reacting with glutathione (GSH) by the redox response, thus avoiding long-term toxicity. In addition, the cellular uptake study and in vivo multispectral optoacoustic tomography (MSOT), X-ray computed tomography (CT), and magnetic resonance (MR) triple-modal images demonstrated that Gd2O3/BSA@MoS2-HA nanoparticles exhibited a high tumor uptake effect after intravenous injection. Consequently, such clearable theranostic nanoparticles with multiple functions, which are applicable in multimodal imaging-guided cancer therapy, might show promise for applications in nanomedical science.