Ferroptosis: A missing puzzle piece in the p53 blueprint?
Ferroptosis: A missing puzzle piece in the p53 blueprint?
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DOI：
10.1080/23723556.2015.1046581
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发表时间：
2016-01-01
影响因子：
2.1
通讯作者：
Gu, Wei
中科院分区：
文献类型：
--
作者：
Wang, Shang-Jui;Ou, Yang;Gu, Wei
Recent evidence indicates that canonical functions of p53 (i.e., apoptosis and growth arrest) are dispensable for p53-mediated tumor suppression. We have uncovered a novel function of p53 that contributes to tumor suppression through regulation of cystine metabolism, reactive oxygen species responses, and ferroptosis. The p53-mediated ferroptotic response via SLC7A11 denotes an extra layer of defense against tumorigenesis in conjunction with other p53 functions.
