Correlation between genetic polymorphism of angiopoietin-2 gene and clinical aspects of rheumatoid arthritis
Correlation between genetic polymorphism of angiopoietin-2 gene and clinical aspects of rheumatoid arthritis
复制标题
血管生成素2基因遗传多态性与类风湿性关节炎临床的相关性
DOI：
10.7150/ijms.30582
复制
发表时间：
2019-01-01
影响因子：
3.6
通讯作者：
Su, Chen-Ming
中科院分区：
文献类型：
--
作者：
Dai, Chengqian;Kuo, Shu-Jui;Su, Chen-Ming
血管生成素-2 （Ang2）基因编码血管生成因子，Ang2基因的多态性可预测各种人类疾病的风险。我们想研究Ang2基因的单核苷酸多态性（snp）是否可以预测类风湿关节炎（RA）的风险。在2016年至2018年期间，我们招募了335名RA患者和700名对照参与者。对snp rs2442598、rs734701、rs1823375和rs12674822进行比较基因分型。我们发现，与携带SNP rs2442598的A/A基因型的受试者相比，携带T/T基因型的受试者发生RA的可能性是携带SNP rs2442598的受试者的1.78倍。SNP rs734701 C/C基因型受试者发生RA的可能性是TT基因型受试者的0.53倍，提示其具有保护作用。SNP rs1823375的GIG基因型受试者发生RA的可能性是C/C基因型受试者的1.77倍。SNP rs11137037的A/C和C/C基因型受试者发生RA的可能性分别是A/A基因型受试者的1.65和2.04倍。SNP rs12674822的G/T和T/T基因型受试者发生RA的可能性分别是G/G基因型受试者的2.42和2.25倍。rs734701以上的T等位基因可导致血清红细胞沉降率升高（p = 0.006）。rs11137037上的A等位基因与发病和采血之间的持续时间较长相关（p = 0.003）。我们的研究提示Ang2可能是RA治疗的诊断标志物和治疗靶点。直接或间接调节Ang2活性的治疗药物可能是治疗RA的有希望的方式。
The Angiopoietin-2 (Ang2) gene encodes angiogenic factor, and the polymorphisms of Ang2 gene predict risk of various human diseases. We want to investigate whether the single nucleotide polymorphisms (SNPs) of the Ang2 gene can predict the risk of rheumatoid arthritis (RA). Between 2016 and 2018, we recruited 335 RA patients and 700 control participants. Comparative genotyping for SNPs rs2442598, rs734701, rs1823375 and rs12674822 was performed. We found that when compared with the subjects with the A/A genotype of SNP rs2442598, the subjects with the T/T genotype were 1.78 times likely to develop RA. The subjects with C/C genotype of SNP rs734701 were 0.53 times likely to develop RA than the subjects with TT genotype, suggesting the protective effect. The subjects with GIG genotype of SNP rs1823375 were 1.77 times likely to develop RA than the subjects with C/C genotype. The subjects with A/C and C/C genotype of SNP rs11137037 were 1.65 and 2.04 times likely to develop RA than the subjects with A/A genotype. The subjects with G/T and T/T genotype of SNP rs12674822 were 2.42 and 2.25 times likely to develop RA than the subjects with G/G genotype. The T allele over rs734701 can lead to higher serum erythrocyte sedimentation rate level (p = 0.006). The A allele over rs11137037 was associated with longer duration between disease onset and blood sampling (p = 0.003). Our study suggested that Ang2 might be a diagnostic marker and therapeutic target for RA therapy. Therapeutic agents that directly or indirectly modulate the activity of Ang2 may be the promising modalities for RA treatment.