MAGNETIC-RESONANCE-IMAGING TECHNIQUES FOR DETECTION OF ELASTICITY VARIATION
MAGNETIC-RESONANCE-IMAGING TECHNIQUES FOR DETECTION OF ELASTICITY VARIATION
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DOI：
10.1118/1.597633
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发表时间：
1995-11-01
期刊：
影响因子：
3.8
通讯作者：
SARVAZYAN, AP
中科院分区：
文献类型：
--
作者：
FOWLKES, JB;EMELIANOV, SY;SARVAZYAN, AP
人工触诊在检测乳腺癌方面的相对成功将表明，一种通过远程触诊来测量组织弹性的方法可以为检测乳房更深层次的癌症病变提供一种诊断工具。这一假设部分是基于肿瘤组织和正常组织之间的良好对比，这是由于剪切弹性模数的较大(数量级)相对差异。相比之下，大多数软组织的整体变形模量值保持在20%以内。一种测量组织位移的特定磁共振成像(MRI)方法已被用于实验，实验中使用了一个包含杨氏模数增加区域的体模作为演示。空间磁化调制技术利用自旋饱和引起的空间网格图案的位移来跟踪区域运动。文中还举例说明了弹性模数分布的数学重建。可以使用能够以足够的空间分辨率检测局部组织运动的任何方式，例如MRI、超声波等，因此这里提出的结果应该给出这样的运动跟踪技术对组织弹性的未来测量的实用性的指示。
The relative success of manual palpation in the detection of breast cancer would suggest that a method for remote palpation resulting in a measurement of tissue elasticity could provide a diagnostic tool for detecting cancerous lesions deeper within the breast. This presumption is based in part on the excellent contrast between neoplastic and normal tissue due to the large (orders of magnitude) relative variation in the shear elastic modulus. By comparison, the bulk deformational modulus maintains the same value to within 20% for most soft tissues. A specific method of magnetic-resonance imaging (MRI) which measures tissue displacements has been used in experiments with a phantom containing regions of increased Young's modulus as a demonstration. The spatial modulation of magnetization technique uses the displacement of a spatial grid pattern caused by spin saturation to track regional motion. Mathematical reconstruction of the distribution of elastic moduli is shown for select examples. Any modality, e.g., MRI, ultrasound, etc., which can detect local tissue motion with sufficient spatial resolution can be used and therefore the results presented here should give an indication of the utility of such motion tracking techniques to future measurement of tissue elasticity.