FACTORS AFFECTING THE CONCENTRATION OF FREE HOLO RETINOL-BINDING PROTEIN IN HUMAN-PLASMA
FACTORS AFFECTING THE CONCENTRATION OF FREE HOLO RETINOL-BINDING PROTEIN IN HUMAN-PLASMA
复制标题
DOI：
10.1111/j.1365-2362.1984.tb02104.x
复制
发表时间：
1984-01-01
影响因子：
5.5
通讯作者：
FELDING, P
中科院分区：
文献类型：
--
作者：
FEX, G;FELDING, P
总浓度的视黄醇，视黄醇结合蛋白和前白蛋白测定血浆从20名健康男性和60例各种炎症条件。这些浓度彼此之间都有很强的相关性，并且在患者组中较低。计算游离的（非前白蛋白结合的）全视黄醇结合蛋白的浓度，推测该蛋白是组织中视黄醇的活性供应者。在患者组中没有下降。在整个材料中测得的总浓度及其可能的比例中，视黄醇/前白蛋白的比例与游离全视黄醇结合蛋白的浓度相关性最强。对文献数据的计算支持了游离全视黄醇结合蛋白浓度对细胞维生素A供应的重要性，表明该浓度优于上述区分正常和异常暗适应能力患者的总浓度。
The total concentrations of retinol, retinol-binding protein and prealbumin were determined in plasma from 20 healthy men and 60 patients with various inflammatory conditions. These concentrations were all strongly correlated to each other and lower in the patient group. The concentration of free (not preablbumin-bound) holo retinol-binding protein, the presumed active supplier of retinol to the tissues, was calculated. It was not decreased in the patient group. Of the measured total concentrations and their possible ratios in the whole material, the retinol/prealbumin ratio showed the strongest correlation to the concentration of free holo retinol-binding protein. The importance of the concentration of free holo retinol-binding protein for the vitamin A supply to the cells was supported by calculations on data from the literature showing that this concentration better than the above-mentioned total concentrations distinguished between patients with normal and abnormal dark adaptation ability.