DNA Walkers for Biosensing Development.
DNA Walkers for Biosensing Development.
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用于生物传感开发的 DNA Walker
DOI：
10.1002/advs.202200327
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发表时间：
2022-06
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DNA纳米材料具有设计任意形状和可控运动的纳米结构的能力，这使得DNA纳米材料被广泛用于构建具有各种结构和功能的纳米机器。DNA纳米结构表现出优异的性能，包括可编程性、稳定性、生物相容性，并且可以用不同的官能团进行修饰。在这些纳米结构中，DNA步行者是设计巧妙、功能灵活的最受欢迎的纳米器件之一。在过去的几年里，DNA步行者已经取得了惊人的进展，从结构设计到生物应用，包括构建用于检测癌症相关生物标志物的生物传感器。在这篇综述中，DNA步行者的关键驱动力进行了总结。然后介绍了不同腿数的DNA步行者。此外，DNA步行者的生物传感应用，包括核酸，蛋白质，离子和细菌的检测进行了总结。最后，新的前沿和发展的DNA步行者-为基础的生物传感器的机会进行了讨论。
The ability to design nanostructures with arbitrary shapes and controllable motions has made DNA nanomaterials used widely to construct diverse nanomachines with various structures and functions. The DNA nanostructures exhibit excellent properties, including programmability, stability, biocompatibility, and can be modified with different functional groups. Among these nanoscale architectures, DNA walker is one of the most popular nanodevices with ingenious design and flexible function. In the past several years, DNA walkers have made amazing progress ranging from structural design to biological applications including constructing biosensors for the detection of cancer‐associated biomarkers. In this review, the key driving forces of DNA walkers are first summarized. Then, the DNA walkers with different numbers of legs are introduced. Furthermore, the biosensing applications of DNA walkers including the detection‐ of nucleic acids, proteins, ions, and bacteria are summarized. Finally, the new frontiers and opportunities for developing DNA walker‐based biosensors are discussed.