CYP2E1 and oxidant stress in alcoholic and non-alcoholic fatty liver disease
CYP2E1 and oxidant stress in alcoholic and non-alcoholic fatty liver disease
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DOI：
10.1016/j.jhep.2012.08.018
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发表时间：
2013-02-01
影响因子：
25.7
通讯作者：
Nieto, Natalia
中科院分区：
文献类型：
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作者：
Leung, Tung-Ming;Nieto, Natalia
酒精性（ALD）和非酒精性脂肪性肝病（NAFLD）是由酒精消耗、高脂肪饮食、肥胖和糖尿病等引起的导致肝细胞损伤和炎症的临床病症。氧化应激是ALD和NAFLD发病机制的主要促成因素。多项研究表明，活性氧（ROS）的产生是脂肪肝进展为脂肪性肝炎的关键。细胞色素P450 2E1（CYP2E1）在ROS产生中起关键作用，并且CYP2E1也由酒精本身诱导。本文就CYP2E1在ALD和NAFLD中的作用作一综述。(C)2012年欧洲肝脏研究协会。Elsevier B.V.出版，保留所有权利。
Alcoholic (ALD) and non-alcoholic fatty liver diseases (NAFLD) are clinical conditions leading to hepatocellular injury and inflammation resulting from alcohol consumption, high fat diet, obesity and diabetes, among others. Oxidant stress is a major contributing factor to the pathogenesis of ALD and NAFLD. Multiple studies have shown that generation of reactive oxygen species (ROS) is key for the progression of fatty liver to steatohepatitis. Cytochrome P450 2E1 (CYP2E1) plays a critical role in ROS generation and CYP2E1 is also induced by alcohol itself. This review summarizes the role of CYP2E1 in ALD and NAFLD. (C) 2012 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.