On the use of PyAOP, a phosphonium salt derived from HOAt, in solid-phase peptide synthesis
On the use of PyAOP, a phosphonium salt derived from HOAt, in solid-phase peptide synthesis
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DOI：
10.1016/s0040-4039(97)01011-3
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发表时间：
1997-07-07
影响因子：
1.8
通讯作者：
Kates, SA
中科院分区：
文献类型：
--
作者：
Albericio, F;Cases, M;Kates, SA
HoAT的磷衍生物，如PyAOP，可用于固相制备一系列多肽，包括那些含有受阻氨基酸、困难短序列和环多肽的多肽。与铀盐相比的一个优点是，过量的吡咯烷酮不会在氨基末端发生有害的副反应，从而阻碍进一步的链组装。(C)1997年，爱思唯尔科学有限公司出版。
Phosphonium derivatives of HOAt such as PyAOP are useful for the solid-phase preparation of a range of peptides that include those incorporating hindered amino acids, difficult short sequences, and cyclic peptides. An advantage relative to uronium salts is that excess PyAOP does not undergo the detrimental side-reaction at the amino terminus which blocks further chain assembly. (C) 1997 Published by Elsevier Science Ltd.