Cell population kinetics of erythroid tissue in the liver of foetal mice.
Cell population kinetics of erythroid tissue in the liver of foetal mice.
复制标题
胎鼠肝脏中红细胞组织的细胞群动力学。
DOI：
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发表时间：
1970
期刊：
影响因子：
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通讯作者：
R. Cole
中科院分区：
文献类型：
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作者：
R. G. Tarbutt;R. Cole
测量了随机繁殖的瑞士胎鼠肝脏中各种类型红系细胞的相对数量和总数。它已被证明，结果可以解释在两个波的红细胞生成通过肝脏，一个大致符合肝红细胞生成的促红细胞生成素敏感期，其他与不敏感期。早期红系细胞的有丝分裂指数和胸苷标记指数在研究期间没有变化，但晚期细胞类型的标记指数从13天的30%下降到18天的15%。这种减少被解释为非分裂多色成红细胞比例的增加。在13和16日龄时测定了胎肝中早期和晚期红系细胞的细胞周期时间。早期细胞的周期时间在两个发育阶段都约为5½ h，但晚期（多色）成红细胞的周期时间从13天的8 h减少到16天的5-6 h。研究表明，所提供的结果与在胎仔生命第15天左右观察到的肝原性红细胞增加率变化一致。
Measurements have been made of the relative and total numbers of the various types of erythroid cells in the livers of random-bred Swiss foetal mice. It has been shown that the results can be interpreted in terms of two waves of erythropoiesis passing through the liver, one coinciding approximately with the erythropoietin sensitive phase of hepatic erythropoiesis, the other with the insensitive phase. The mitotic index and thymidine labelling index of early erythroid cells do not change during the period studied, but the labelling index of the late cell types decreases from 30% at 13 days to 15% at 18 days. This decrease has been interpreted as an increase in the proportion of non-dividing polychromatic erythroblasts. The cell cycle time of early and late erythroid cells in foetal livers has been determined at 13 and 16 days of age. The cycle time of the early cells is about 5½ h at both stages of development, but that of late (polychromatic) erythroblasts decreases from 8 h at 13 days to 5–6 h at 16 days. It has been shown that the results presented are consistent with the change in the rate of increase of hepatogenic red cells which is observed at about the 15th day of foetal life.