Testosterone differentially influences sex-specific pheromone-stimulated fos expression in limbic regions of syrian hamsters
Testosterone differentially influences sex-specific pheromone-stimulated fos expression in limbic regions of syrian hamsters
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DOI：
10.1006/hbeh.1996.0050
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发表时间：
1996-12-01
影响因子：
3.5
通讯作者：
Swann, JM
中科院分区：
文献类型：
--
作者：
Fiber, JM;Swann, JM
本研究结果表明：(1)信息素在调节交配行为的通路中对雄性和雌性神经元的刺激存在差异；(2)睾酮(T)对这些性别差异有不同的调节作用。暴露于雌性仓鼠阴道分泌物中的信息素可诱导雄性和雌性仓鼠在杏仁核内侧后亚区（MeP）和尾纹床核内侧后亚区（BNSTpm）的Fos免疫反应性（Fos- ir），并刺激内侧视前核（MPNmag）的大细胞亚区（MPNmag）。男性在MeP和BNSTpm中也比女性表现出更多的Fos。在没有T的情况下，性腺去角质的雄性在BNSTpm和MeP中显示出比性腺去角质的雌性更大的fhvs刺激的Fos-IR。雌性体内的T消除了这些区域的性别差异。只有经T处理的雄性在MPNmag内显示fhvs刺激的Fos-IR，而T对雌性MPNmag内fhvs刺激的Fos-IR没有影响。因此，T影响fhvs刺激下雌性BNSTpm和MeP的Fos-IR以及雄性MPNmag。T也会增加雄性和雌性对FHVS的调查（嗅探和舔舐），但只会增加雄性的交配反应。我们的研究结果表明，成年仓鼠的T对雄性和雌性暴露于信息素时的神经和行为反应有不同的影响，T只部分解释了观察到的性别差异，发育过程中的神经组织可能也在影响对信息素的反应中起作用。(C) 1996年学术出版社。
The results of the present study indicate that (1) pheromones differentially stimulate neurons in males and females within a pathway that regulates copulatory behavior; and (2) testosterone (T) differentially regulates these sex differences, Exposure to the pheromones in FHVS (female hamster vaginal secretions) induces Fos immunoreactivity (Fos-IR) in the posterior subdivision of the medial nucleus of the amygdala (MeP) and the posteromedial subdivision of the bed nucleus of the stria terminalis (BNSTpm) of both sexes and stimulates the magnocellular subdivision of the medial preoptic nucleus (MPNmag) in males but not in females, Males also show more Fos in the MeP and BNSTpm than females. In the absence of T, gonadectomized males show greater FHVS-stimulated Fos-IR in the BNSTpm and MeP than gonadectomized females. T in females eliminates the sex difference in these regions. Only T-treated males show FHVS-stimulated Fos-IR within the MPNmag, and T has no effect on FHVS-stimulated Fos-IR within MPNmag in females. Thus, T influences FHVS-stimulated Fos-IR in the BNSTpm and MeP of females and the MPNmag of males. T also increases investigation (sniffing and licking) of FHVS in both males and females, but increases copulatory responses only in males. Our results indicate that T in the adult hamster differentially influences neural and behavioral responses to pheromone exposure in males and females, T only partially accounts for observed sex differences, and it is likely that neural organization during development also plays a role in influencing responses to pheromones. (C) 1996 Academic Press.