Cytokine Networks and T-Cell Subsets in Inflammatory Bowel Diseases.
Cytokine Networks and T-Cell Subsets in Inflammatory Bowel Diseases.
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DOI：
10.1097/mib.0000000000000714
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发表时间：
2016-05
影响因子：
4.9
通讯作者：
Sundrud MS
中科院分区：
文献类型：
--
作者：
Chen ML;Sundrud MS
炎症性肠病（IBD）、溃疡性结肠炎（UC）和克罗恩病（CD）的发病机制涉及微生物群内的促炎性变化、慢性免疫介导的炎症反应和上皮功能障碍。来自全基因组关联研究（GWAS）、IBD小鼠模型和临床试验的聚合数据表明，细胞因子是肠道正常稳态和慢性炎症的关键效应子。然而，关于特定细胞因子在不同IBD中的作用，在肠道的不同区域内，以及关于细胞作用机制，仍然存在许多问题。在这里，我们回顾了当前和新兴的概念，细胞因子在IBD中的作用，重点是免疫调节，T细胞亚群和潜在的临床应用。
Pathogenesis of the inflammatory bowel diseases (IBDs) ulcerative colitis (UC) and Crohn’s disease (CD) involve pro-inflammatory changes within the microbiota, chronic immune-mediated inflammatory responses, and epithelial dysfunction. Converging data from genome-wide association studies (GWAS), mouse models of IBD, and clinical trials indicate that cytokines are key effectors of both normal homeostasis and chronic inflammation in the gut. Yet still many questions remain concerning the role of specific cytokines in different IBDs, within distinct regions of the gut, and with regard cellular mechanisms of action. Here we review current and emerging concepts concerning the role of cytokines in IBD, with a focus on immune regulation, T cell subsets, and potential clinical applications.