REGULATORY EFFECTS OF BIFIDOBACTERIA ON THE GROWTH OF OTHER COLONIC BACTERIA
REGULATORY EFFECTS OF BIFIDOBACTERIA ON THE GROWTH OF OTHER COLONIC BACTERIA
复制标题
DOI：
10.1111/j.1365-2672.1994.tb03443.x
复制
发表时间：
1994-10-01
期刊：
影响因子：
--
通讯作者：
WANG, X
中科院分区：
文献类型：
--
作者：
GIBSON, GR;WANG, X
在人类大肠中，双歧杆菌是一个重要的微生物群，被认为发挥一系列与宿主健康相关的生物活性。一方面是这些细菌对其他物种的抑制作用，可能排除了入侵病原体的长期定植。有人认为，双歧杆菌的抑制作用机制与醋酸和乳酸等酸的发酵生产有关。本文报道的实验试图解决这一理论。婴儿双歧杆菌与大肠杆菌和产气荚膜梭菌在不同的发酵系统中共同培养的实验表明，双歧杆菌能够发挥抑制作用，而不一定与产酸有关。进一步的研究表明，8种双歧杆菌能够以不同的方式分泌具有广谱活性的抗微生物物质。沙门氏菌属、李斯特菌属、弯曲杆菌属、志贺氏菌属以及霍乱弧菌属均受影响。这些结果表明，双歧杆菌能够发挥不止一种抑制机制，这可能在预防胃肠炎方面具有一定的重要性。
In the human large intestine bifidobacteria are a numerically important group of micro-organisms which are considered to exert a range of biological activities related to host health. One aspect is the inhibitory effect of these bacteria on other species, possibly excluding long term colonization by invasive pathogens. It has been suggested that the mechanism of inhibition carried out by bifidobacteria is related to the fermentative production of acids such as acetate and lactate. Experiments reported in this paper attempted to address this theory. Co-culture experiments whereby Bifidobacterium infantis was incubated with Escherichia coli and Clostridium perfringens, in a variety of fermentation systems, indicated that the bifidobacterium was able to exert an inhibitory effect not necessarily related to acid production. Further studies showed that eight species of bifidobacteria could variously excrete an anti-microbial substance with a broad spectrum of activity. Species belonging to the genera Salmonella, Listeria, Campylobacter and Shigella, as well as Vibrio cholerae, were all affected. These results show that bifidobacteria are able to exert more than one mechanism of inhibition, which may be of some importance with regard to protection against gastroenteritis.