Prevalence and assemblage of Giardia duodenalis in a case-control study of children under 5 years from Jimma, Southwest Ethiopia.
Prevalence and assemblage of Giardia duodenalis in a case-control study of children under 5 years from Jimma, Southwest Ethiopia.
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埃塞俄比亚西南部Jimma地区5岁以下儿童贾第鞭毛虫病的患病率和聚集情况的病例对照研究
DOI：
10.1007/s00436-023-08029-5
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发表时间：
2023-12-13
影响因子：
2
通讯作者：
中科院分区：
文献类型：
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作者：
十二指肠贾第虫是一种常见的致病性肠道原生动物寄生虫，在发展中国家，尤其是儿童中发病率很高。贾第鞭毛虫在人类中的分布及其临床相关性仍然存在争议。本研究旨在确定贾第鞭毛虫在埃塞俄比亚西南部吉马5岁以下儿童中的流行和聚集情况。采用病例对照设计，2016年12月至2018年7月，在吉马大学医学中心和塞尔维亚卫生中心招募了606名腹泻儿童，同时招募了617名无腹泻的匹配对照组。采用实时PCR检测贾第鞭毛虫并分型。进行单因素和多因素回归分析。贾第鞭虫总患病率为41%(501/1223)，在病例和对照组之间无显著差异（40% vs 42%）。患病率随年龄增长而增加，年龄≥25个月的儿童患病率最高。与没有腹泻史的儿童相比，上个月有腹泻史的无腹泻儿童贾第虫阳性的可能性更大（OR 1.8和95%CI； 1.1-2.9）。无论目前的腹泻症状如何，组合B占89%，其次是组合A（8%）和混合感染组合A和B（3%）。我们报告了贾第鞭毛虫的高流行率的PCR检测在吉马，埃塞俄比亚，与组合B为主。在有腹泻和没有腹泻的儿童中，贾第鞭毛虫的聚集分布相似。年龄增长是贾第虫感染的危险因素。需要采用以社区为基础的预防和控制战略来降低贾第鞭毛虫感染的风险。
Giardia duodenalis is a common pathogenic intestinal protozoan parasite with high prevalence in developing countries, especially among children. The distribution of giardia assemblages among humans and their clinical relevance remains controversial. This study aimed to determine the prevalence and assemblage of Giardia among children under 5 years of age in Jimma, Southwest Ethiopia. Employing a case-control design, 606 children presenting with diarrhea at Jimma university medical center and Serbo Health Center were enrolled from December 2016 to July 2018 along with 617 matched controls without diarrhea. Giardia was detected and typed using real-time PCR. Univariate and multivariate regression analysis was performed. The total prevalence of Giardia was 41% (501/1223) and did not differ significantly between cases and controls (40% vs 42%). Prevalence increased by age, with the highest prevalence seen in children aged ≥ 25 months. Children without diarrhea with a history of diarrhea during the last month were more likely to be Giardia positive compared to children with no history diarrhea (OR 1.8 and 95%CI; 1.1–2.9). Regardless of current diarrhea symptoms, assemblage B predominated with 89%, followed by assemblage A (8%) and mixed infection assemblage A and B (3%). We report a high prevalence of Giardia by PCR detection in Jimma, Ethiopia, with assemblage B being predominant. There was a similar distribution of Giardia assemblages between children with and without diarrhea. Increasing age was a risk factor for Giardia infection. Community-based prevention and control strategies need to be employed to decrease the risk of giardia infection.
影响因子：
8.1
作者：
Damitie M;Mekonnen Z;Getahun T;Santiago D;Leyns L
通讯作者：
Leyns L