Identification and characterization of a novel member of murine semaphorin family
Identification and characterization of a novel member of murine semaphorin family
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DOI：
10.1111/j.1365-2443.2005.00877.x
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发表时间：
2005-08
期刊：
影响因子：
2.1
通讯作者：
M. Taniguchi;T. Masuda;M. Fukaya;Hirotaka Kataoka;M. Mishina;H. Yaginuma;Masahiko Watanabe;Takao Shimizu
中科院分区：
文献类型：
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作者：
M. Taniguchi;T. Masuda;M. Fukaya;Hirotaka Kataoka;M. Mishina;H. Yaginuma;Masahiko Watanabe;Takao Shimizu
信号蛋白基因家族包含大量分泌型或跨膜型蛋白，其中一些在发育过程中作为轴突引导的排斥和吸引信号。在这里，我们报道了小鼠3类信号蛋白基因的一个新成员，信号蛋白3G (Sema3G)，定位在染色体14上。成年后，Sema3G主要在肺和肾中表达，少量在脑中表达。有趣的是，在成年啮齿动物的大脑中，Sema3G仅在小脑的颗粒层中表达，这是通过Northern blot和原位杂交分析确定的。我们还发现Sema3G结合Neuropilin‐2而不是Neuropilin‐1，并诱导交感轴突的排斥，而不是背根神经节轴突，这表明Sema3G利用Neuropilin‐2作为受体来排斥特定类型的轴突。
The semaphorin gene family contains a large number of secreted type or transmembrane type proteins, and some of them function as the repulsive and attractive cues of axon guidance during development. Here we report a novel member of murine class 3 semaphorin genes, semaphorin 3G (Sema3G), mapped on chromosome 14. In adulthood, Sema3G is mainly expressed in the lung and kidney, and a little in the brain. Interestingly, in the adult rodent brain Sema3G is expressed only in the granular layer of the cerebellum, as determined by Northern blot and in situ hybridization analyses. We also found that Sema3G binds Neuropilin‐2, but not Neuropilin‐1, and induces the repulsion of sympathetic axons, but not dorsal root ganglion axons, indicating that Sema3G utilizes Neuropilin‐2 as a receptor to repel specific types of axons.