Prefrontal hypofunction in patients with intractable mesial temporal lobe epilepsy
Prefrontal hypofunction in patients with intractable mesial temporal lobe epilepsy
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DOI：
10.1212/01.wnl.0000242628.26978.e2
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发表时间：
2006-11
期刊：
影响因子：
9.9
通讯作者：
S. Takaya;Takashi Hanakawa;Kazuo Hashikawa;Akio Ikeda;N. Sawamoto;Takashi Nagamine;Koichi Ishizu
中科院分区：
文献类型：
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作者：
S. Takaya;Takashi Hanakawa;Kazuo Hashikawa;Akio Ikeda;N. Sawamoto;Takashi Nagamine;Koichi Ishizu
我们比较了11例发作频繁的内侧颞叶癫痫(MTLE)和10例罕见发作的MTLE患者的认知功能和发作间期脑葡萄糖代谢，两组在年龄、性别、教育程度、智商和病灶侧匹配。频发组前额叶皮质SET-Shift障碍较多，与葡萄糖代谢低下有关。我们的结果表明，MTLE的频繁发作与前额叶皮质功能低下有关。
We compared the cognitive functions and interictal cerebral glucose metabolism of 11 patients with mesial temporal lobe epilepsy (MTLE) with frequent seizures to those of 10 patients with MTLE with rare seizures; the groups were matched for age, sex, education, IQ, and focus side. The frequent-seizure group had more set-shifting impairment that correlated with glucose hypometabolism in the prefrontal cortices. Our results suggest that frequent seizures in MTLE are associated with hypofunction of the prefrontal cortex.