Low molecular weight copper binding proteins in Wilson disease.
Low molecular weight copper binding proteins in Wilson disease.
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威尔逊病中的低分子量铜结合蛋白。
DOI：
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发表时间：
1985
期刊：
影响因子：
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通讯作者：
I. Wald
中科院分区：
文献类型：
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作者：
M. Rodo;H. Wehr;I. Wald
培养的成纤维细胞来源于威尔逊病患者进行了比较与控制方面的铜积累和低分子量铜结合蛋白（金属硫蛋白）的属性。没有证据表明金属硫蛋白异常可能是Wilson病铜代谢紊乱的主要原因。静脉注射64Cu后24小时血清低分子量组分中的放射性测定已被建议作为Wilson病可疑病例诊断的附加工具。
Cultured fibroblasts deriving from Wilson disease patients were compared with the control ones in respect of copper accumulation and low molecular weight copper binding protein (metallothionein) properties. No evidence was obtained that metallothionein abnormality could be a primary cause of copper metabolism disturbances in Wilson disease. The determination of radioactivity, present in serum low molecular weight fraction 24 hours after intravenous injection of 64Cu, has been suggested as an additional tool in Wilson disease diagnosis in doubtful cases.