Cell potential of isolated outer hair cells as a function of extracellular K+ concentration.

Cell potential of isolated outer hair cells as a function of extracellular K+ concentration.
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分离的外毛细胞的细胞电位作为细胞外 K 浓度的函数。

DOI:
10.1159/000276343
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发表时间:
1993
期刊:
ORL; journal for oto-rhino-laryngology and its related specialties
影响因子:
--
通讯作者:
A. Gitter
A. Gitter
中科院分区:
--
文献类型:
--
作者:
A. Gitter

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从豚鼠耳蜗顶端匝部分离出外毛细胞。在含钾量为5.8、14.0、28.9和67.5 mmol/l的细胞外培养基中,细胞的膜电位差分别为-72.0 +/- 0.6(平均+/- SEM, n = 93)、-50.1 +/- 2.1 (n = 4)、-37.7 +/- 0.5 (n = 73)和-20.0 +/- 1.5 mV (n = 16)。膜去极化可以解释三分之二的K(+)诱导的离体外毛细胞缩短。
Outer hair cells were isolated from apical turns of the guinea pig cochlea. The membrane potential differences of cells in extracellular medium with 5.8, 14.0, 28.9 or 67.5 mmol/l of potassium were -72.0 +/- 0.6 (mean +/- SEM, n = 93), -50.1 +/- 2.1 (n = 4), -37.7 +/- 0.5 (n = 73) or -20.0 +/- 1.5 mV (n = 16), respectively. Membrane depolarization can explain two thirds of the K(+)-induced shortening of isolated outer hair cells.