Self-injurious behavior in young boys with fragile X syndrome
Self-injurious behavior in young boys with fragile X syndrome
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DOI：
10.1002/ajmg.a.10078
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发表时间：
2003-04-15
影响因子：
2
通讯作者：
Bailey, DB
中科院分区：
文献类型：
--
作者：
Symons, FJ;Clark, RD;Bailey, DB
在这项研究中，我们对67个患有脆性X综合征的男孩家庭进行了调查，以确定自我伤害行为的患病率、发病、形式、功能、位置和相关因素。完成了55项调查（82%）。调查时男孩的平均年龄为80个月（范围= 20-144）。58%的参与者报告了自我伤害行为（SIB），平均发病年龄为31个月。每名参与者的自伤形式平均为2种。咬伤是最常见的自伤形式，手指和手背不成比例地成为最常见的自伤身体部位。SIB的风险没有随着年龄超过25个月而线性增加。据报告，SIB最有可能发生在提出困难的任务要求或改变常规之后。与没有自伤的男孩相比，有自伤的男孩的问题行为的总体评分存在显著的组间差异。各组在脆性X智力低下蛋白（FMRP）、自闭症状态、适应行为或首次用药年龄方面没有差异。结果进行了讨论，在未来的研究旨在进一步阐明脆性X综合征的行为表型。(C)2003 Wiley-Liss，Inc.
In this study, we distributed surveys to 67 families of young boys with fragile X syndrome to determine the prevalence, onset, form, function, location, and correlates of self-injurious behavior. Fifty-five surveys were completed (82%). The mean age of the boys at the time of the survey was 80 months (range = 20-144). Self-injurious behavior (SIB) was reported for 58% of the participants with a mean age of onset of 31 months. The mean number of forms of self-injury was 2 per participant. Biting was the most commonly reported form of self-injury with the fingers and back of the hand disproportionately targeted as the most prevalent self-injury body site. There was no linear increase in risk of SIB with age past 25 months. SIB was reported as most likely to occur following the presentation of difficult task demands or changes in routine. Significant group differences were found between overall ratings of problem behavior for boys with self-injury compared to those without self-injury. Groups did not differ on measures of fragile X mental retardation protein (FMRP), autism status, adaptive behavior, or age first medicated. Results are discussed in terms of future research designed to further elucidate the behavioral phenotype of fragile X syndrome. (C) 2003 Wiley-Liss, Inc.