A wireless, solar-powered, optoelectronic system for spatial restriction-free long-term optogenetic neuromodulations.
A wireless, solar-powered, optoelectronic system for spatial restriction-free long-term optogenetic neuromodulations.
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DOI：
10.1126/sciadv.adi8918
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发表时间：
2023-09-29
期刊：
影响因子：
13.6
通讯作者：
Yu, Ki Jun
中科院分区：
文献类型：
--
作者：
Park, Jaejin;Kim, Kyubeen;Kim, Yujin;Kim, Tae Soo;Min, In Sik;Li, Bowen;Cho, Young Uk;Lee, Chanwoo;Lee, Ju Young;Gao, Yuyan;Kang, Kyowon;Kim, Do Hyeon;Choi, Won Jun;Shin, Hyun-Beom;Kang, Ho Kwan;Song, Young Min;Cheng, Huanyu;Cho, Il-Joo;Yu, Ki Jun
许多无线光遗传系统已被报道用于自由移动动物的实际无系绳光遗传。然而，大多数设备依赖于电池供电或线圈供电的系统，需要定期更换电池或体积庞大、成本高昂的充电设备，这些设备带有精密的天线设计。这导致了时空限制，例如由于电池寿命而限制的实验时间或动物在特定区域内限制运动以保持无线电力传输。在这项研究中，我们提出了一种无线、太阳能供电、柔性光电装置，用于神经调节完全自由行为的主体。该设备提供长期运行，无需更换电池或其他外部设置，包括阻抗匹配技术和射频发生器。我们的设备采用高效，薄InGaP/GaAs串联柔性光伏电池从各种光源中收集能量，为蓝牙系统提供动力，以促进长期按需使用。通过次级运动皮层区域刺激对小鼠持续一个月的运动行为的观察表明，我们的设备具有显著的能力，突出了其在无空间神经调节应用方面的潜力。太阳能光遗传系统长期刺激受试者，不需要任何外部充电设备和空间限制。
Numerous wireless optogenetic systems have been reported for practical tether-free optogenetics in freely moving animals. However, most devices rely on battery-powered or coil-powered systems requiring periodic battery replacement or bulky, high-cost charging equipment with delicate antenna design. This leads to spatiotemporal constraints, such as limited experimental duration due to battery life or animals’ restricted movement within specific areas to maintain wireless power transmission. In this study, we present a wireless, solar-powered, flexible optoelectronic device for neuromodulation of the complete freely behaving subject. This device provides chronic operation without battery replacement or other external settings including impedance matching technique and radio frequency generators. Our device uses high-efficiency, thin InGaP/GaAs tandem flexible photovoltaics to harvest energy from various light sources, which powers Bluetooth system to facilitate long-term, on-demand use. Observation of sustained locomotion behaviors for a month in mice via secondary motor cortex area stimulation demonstrates the notable capabilities of our device, highlighting its potential for space-free neuromodulating applications. A solar-powered optogenetic system chronically stimulates subjects without any external charging equipment and spatial limits.
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DOI：
10.1126/science.1232437
发表时间：
2013-04-12
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Kim TI;McCall JG;Jung YH;Huang X;Siuda ER;Li Y;Song J;Song YM;Pao HA;Kim RH;Lu C;Lee SD;Song IS;Shin G;Al-Hasani R;Kim S;Tan MP;Huang Y;Omenetto FG;Rogers JA;Bruchas MR
通讯作者：
Bruchas MR
影响因子：
9.5
作者：
Kim, Tae Soo;Kim, Hyo Jin;Yu, Ki Jun
通讯作者：
Yu, Ki Jun
影响因子：
2.4
作者：
Lee, Y. H.;Park, K. W.;Lee, Y. T.
通讯作者：
Lee, Y. T.
影响因子：
5.1
作者：
Liu Wen;Li Yueqiang;Yang Fuhua
通讯作者：
Yang Fuhua
影响因子：
48
作者：
Montgomery KL;Yeh AJ;Ho JS;Tsao V;Mohan Iyer S;Grosenick L;Ferenczi EA;Tanabe Y;Deisseroth K;Delp SL;Poon AS
通讯作者：
Poon AS