Repeated treatment with imipramine potentiates the locomotor effect of apomorphine administered into the hippocampus in rats
Repeated treatment with imipramine potentiates the locomotor effect of apomorphine administered into the hippocampus in rats
复制标题
反复用丙咪嗪治疗可增强阿朴吗啡注入大鼠海马的运动效果
DOI：
10.1007/bf00427910
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发表时间：
2004
影响因子：
3.4
通讯作者：
J. Maj
中科院分区：
文献类型：
--
作者：
A. Śmiałowski;J. Maj
研究了海马背侧注射阿扑吗啡对丙咪嗪处理大鼠自发活动的影响。大鼠在丙咪嗪治疗前1周长期植入插管。丙咪嗪以10 mg/kg的剂量经口急性给药，或每日2次，连续14天。海马内注射阿扑吗啡诱导自发活动的剂量依赖性增加。预处理pimozide（2 mg/kg）可拮抗这种作用。重复，但不是单次，丙咪嗪管理显着增强阿扑吗啡诱导的运动过度活跃的大鼠。在丙咪嗪末次给药后2、48和96 h观察到这种效应。所获得的结果表明，丙咪嗪的重复给药增加海马多巴胺能系统的反应性。
The effect of apomorphine, injected into the dorsal hippocampus, on the locomotor activity of imipraminetreated rats was studied. The rats were chronically implanted with cannulae 1 week before imipramine treatment. Imipramine was given in a dose of 10 mg/kg per os, acutely, or twice a day for 14 days. Intrahippocampal injection of apomorphine induced a dose-dependent increase in locomotor activity. This effect was antagonized by pretreatment with pimozide (2 mg/kg). Repeated, but not single, administrations of imipramine significantly enhanced the apomorphine-induced locomotor hyperactivity in rats. This effect was observed at 2, 48 and 96 h after the last dose of imipramine. The results obtained indicate that repeated administration of imipramine increases the responsiveness of the hippocampal dopaminergic system.