The prevalence of VAIN, CIN, and related HPV genotypes in Japanese women with abnormal cytology
The prevalence of VAIN, CIN, and related HPV genotypes in Japanese women with abnormal cytology
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DOI：
10.1002/jmv.25611
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发表时间：
2019-11-18
影响因子：
12.7
通讯作者：
Sasagawa, Toshiyuki
中科院分区：
文献类型：
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作者：
Zhang, Shitai;Saito, Mayumi;Sasagawa, Toshiyuki
阴道上皮内瘤变（VAIN）通常是偶然发现的。我们调查了与宫颈上皮内瘤变（CIN）相比，VAIN和相关的人乳头瘤病毒（HPV）类型的患病率。本研究纳入了2009年1月至2019年1月因细胞学异常而转诊至金泽医科大学医院门诊的648名女性。使用Genosearch-31 + 4确定HPV基因型，其可以检测35种不同的HPV类型。阴道镜检查在第一次就诊时由经验丰富的妇科肿瘤学家进行。在611例鳞状细胞病变受试者中，确定了107例（17.5%）VAIN病例，67例（11.0%）女性同时患有VAIN和CIN。最终，确定了72例VAIN 1，15例VAIN 2/3，203例CIN 1，249例CIN 2/3，32例宫颈鳞状细胞癌（SCC）和1例阴道SCC（Vag-SCC）。VAIN 1、VAIN 2/3和Vag-SCC的患病率分别为35.5%、6.0%和3.1%。VAIN患者年龄大于CIN患者（P = .002）。大约一半的VAIN病例在随访期间被诊断出来。42.9%的VAIN和CIN患者存在多种HPV感染。VAIN中以HPV 52、16、51、53和56型最常见，CIN中以HPV 16、52、58、51和31型为主。VAIN中HPV 18少见，CIN中HPV 58较VAIN多见，VAIN中HPV 53和HPV 73多见。总之，VAIN 1比我们预期的更频繁地被发现。在阴道中发现了各种HPV类型，这可能是HPV的储存库。
Vaginal intraepithelial neoplasia (VAIN) is often found by chance. We investigated the prevalence of VAIN and related human papillomavirus (HPV) types in comparison with cervical intraepithelial neoplasia (CIN). This study enrolled 648 women who were referred to the outpatient clinic of Kanazawa Medical University Hospital for abnormal cytology from January 2009 to January 2019. HPV genotypes were determined using Genosearch-31 + 4, which can detect 35 different HPV types. Colposcopy was performed at the first visit by an experienced gynecological oncologist. Among 611 subjects with squamous cell lesions, 107 (17.5%) VAIN cases were identified, and 67 (11.0%) women had both VAIN and CIN. Ultimately, 72 VAIN1, 15 VAIN2/3, 203 CIN1, 249 CIN2/3, 32 cervical squamous cell carcinomas (SCC), and one vaginal SCC (Vag-SCC) were identified. The prevalences of VAIN1, VAIN2/3, and Vag-SCC were 35.5%, 6.0%, and 3.1% of equivalent cervical lesions, respectively. The VAIN patients were older than the CIN patients (P = .002). About half of the VAIN cases were diagnosed during the follow-up. Multiple HPV infections were found in 42.9% of the VAIN and CIN patients. HPV52, 16, 51, 53, and 56 were the most common types in VAIN, whereas HPV16, 52, 58, 51, and 31 predominated in CIN. HPV18 was rare in VAIN, HPV58 was more common in CIN than in VAIN, and HPV53 and HPV73 were more common in VAIN. In conclusion, VAIN1 was identified more frequently than we expected. Various HPV types were identified in the vagina, which is likely a reservoir for HPV.