Heat-induced longevity extension in Drosophila .1. Heat treatment, mortality, and thermotolerance
Heat-induced longevity extension in Drosophila .1. Heat treatment, mortality, and thermotolerance
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DOI：
10.1093/gerona/52a.1.b48
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发表时间：
1997-01-01
影响因子：
5.1
通讯作者：
Curtsinger, JW
中科院分区：
文献类型：
--
作者：
Khazaeli, AA;Tatar, M;Curtsinger, JW
为了研究轻度热应激后黑腹果蝇的死亡模式和诱导的生理反应，研究人员收集了28000只成年黑腹果蝇的生存数据。与未处理的相同基因型对照相比，在常温下，短暂的非致死热处理使成虫寿命平均延长2天（64天）。预期寿命的延长是在热处理后长达几周的时间内降低年龄死亡率的人口统计学结果。热处理还增加了对后续更严重的热应力的耐受性。对单性种群的观察表明，热诱导的寿命延长与生殖活动的抑制无关。
Survival data were collected on a total of 28,000 Drosophila melanogaster adults in order to investigate mortality patterns and induced physiological responses after a mild thermal stress. A brief, nonlethal heat treatment extends adult life span at normal temperatures by an average of 2 days (64), compared to nontreated controls of the same genotypes. Life expectancy is extended as a demographic consequence of reduced age-specific mortality over a period of up to several weeks after the heat treatment. Heat treatment also increases tolerance to subsequent, more severe thermal stress. Observations on single-sex populations suggest that heat-induced longevity extension is independent of the suppression of reproductive activity.