THE STRENGTH OF A CALCIFIED TISSUE DEPENDS IN PART ON THE MOLECULAR-STRUCTURE AND ORGANIZATION OF ITS CONSTITUENT MINERAL CRYSTALS IN THEIR ORGANIC MATRIX
THE STRENGTH OF A CALCIFIED TISSUE DEPENDS IN PART ON THE MOLECULAR-STRUCTURE AND ORGANIZATION OF ITS CONSTITUENT MINERAL CRYSTALS IN THEIR ORGANIC MATRIX
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DOI：
10.1016/8756-3282(95)00076-p
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发表时间：
1995-05-01
期刊：
影响因子：
4.1
通讯作者：
LANDIS, WJ
中科院分区：
文献类型：
--
作者：
LANDIS, WJ
高压电子显微断层扫描（3D）研究了多种钙化组织中矿物和有机基质之间的超微结构相互作用，揭示了与各自有机基质相关的不同晶体结构和组织特征。在脆性或弱病理性或异位钙化中，包括成骨不全症、钙化反应、钙化症和皮肌炎，羟基磷灰石晶体以各种大小和形状出现，并以不同于正常钙化组织的方式与胶原蛋白定向和排列。提出了一个胶原蛋白-矿物相互作用的模型，该模型可以解释观察到的晶体结构和组织。结果表明，钙化组织提供的最终强度、支撑力和其他机械性能部分取决于其有机基质中组成矿物晶体的分子结构和排列。
High-voltage electron-microscopic tomographic (3D) studies of the ultrastructural interaction between mineral and organic matrix in a variety of calcified tissues reveal different crystal structural and organizational features in association with their respective organic matrices. In brittle or weak pathologic or ectopic calcifications, including examples of osteogenesis imperfecta, calciphylaxis, calcergy, and dermatomyositis, hydroxyapatite crystals occur in various sizes and shapes and are oriented and aligned with respect to collagen in a manner which is distinct from that found in normal calcified tissues. A model of collagen-mineral interaction is proposed which may account for the observed crystal structures and organization. The results indicate that the ultimate strength, support, and other mechanical properties provided by a calcified tissue are dependent in part upon the molecular structure and arrangement of its constituent mineral crystals within their organic matrix.