Gadolinium-based hybrid nanoparticles as a positive MR contrast agent
Gadolinium-based hybrid nanoparticles as a positive MR contrast agent
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DOI：
10.1021/ja066442d
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发表时间：
2006-11-29
影响因子：
15
通讯作者：
Suzuki, Koji
中科院分区：
文献类型：
--
作者：
Hifumi, Hiroki;Yamaoka, Seiichi;Suzuki, Koji
一种新的纳米颗粒无机-有机混合型阳性造影剂（CA），PGP/右旋糖酐-K 01，是基于GdPO 4无机核作为弛豫时间缩短部分和右旋糖酐涂层合成的，其在水中产生单核苷酸，通过在核附近保留大量水分子来实现高度弛豫时间缩短效果，并在体内研究中降低毒性。该PGP/葡聚糖-K 01纳米颗粒具有较高的r1和r2值以及显著较低的r2/r1值1.1，这是前所未有的，并且是现有纳米颗粒CA中的最低值，表明PGP/葡聚糖-K 01是阳性造影剂。由于这种低r2/r1值和纳米颗粒形状，PGP/葡聚糖-K 01将是基于氧化铁的阴性CA的有用的临床替代品。
A new nanoparticulate inorganic−organic hybrid-type positive contrast agent (CA), PGP/dextran-K01, was synthesized based on a GdPO4inorganic core as a relaxation-time-shortening moiety and a dextran-coating, which generates monodispersibility in water, a high relaxation-time-shortening effect by retaining a large number of water molecules in proximity of the core and toxicity reduction in in-vivo studies. This PGP/dextran-K01 nanoparticle has highr1andr2values and a significantly lowr2/r1value, 1.1, which is unprecedented and which is the lowest value among existing nanoparticulate CAs indicating that PGP/dextran-K01 is a positive contrast agent. Because of this lowr2/r1value and the nanoparticulate shape, PGP/dextran-K01 will be a useful clinical substitute for negative CAs based on iron oxides.