Neuronal activity controls the development of interneurons in the somatosensory cortex.
Neuronal activity controls the development of interneurons in the somatosensory cortex.
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神经元活性控制体感皮质中神经元的发展。
DOI：
10.1007/s11515-016-1427-x
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发表时间：
2016-12
期刊：
影响因子：
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通讯作者：
De Marco Garcia N
中科院分区：
文献类型：
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作者：
Babij R;De Marco Garcia N
皮层区域的神经元活动通过与确定的遗传程序相互作用来形成成熟的中枢神经系统，从而调节神经发育。电活动通过皮质内和丘脑皮质神经元传递到感觉皮质区域，并包括在皮质区域测量的振荡模式。在这项工作中，我们回顾了关于电活动如何塑造体感觉皮层功能电路的发育组装的最新发现，重点是中间神经元的成熟和整合。我们包括各种神经递质的作用和丘脑皮层传入活动对回路发育的影响的研究。我们还回顾了描述网络活动模式的研究。我们使用PubMed和谷歌Scholar搜索引擎进行了广泛的文献检索。在不同的迭代中使用了以下关键词：“中间神经元”、“体感”、“发育”、“活动”、“网络模式”、“丘脑皮质”、“NMDA受体”、“可塑性”。我们还选择了我们从过去的阅读中了解的论文，以及审稿人和实验室成员推荐给我们的论文。我们回顾了132篇关于活动在神经元间迁移、成熟和电路发育中的作用的文章，以及电输入的来源和体感觉皮层皮层活动的模式。本次及时回顾的79篇论文写于2007年至2016年之间。神经元活动决定了体感觉皮层中间神经元功能回路的发育组装。这种活动几乎影响了成熟神经元特征的发育和获得的各个方面，并可能有助于改变成人的表型、改变递质表达和可塑性。逐渐变化的振荡网络模式有助于产后早期的这种活动，尽管对活动的具体模式和起源的直接要求仍有待证明。
Neuronal activity in cortical areas regulates neurodevelopment by interacting with defined genetic programs to shape the mature central nervous system. Electrical activity is conveyed to sensory cortical areas via intracortical and thalamocortical neurons, and includes oscillatory patterns that have been measured across cortical regions. In this work, we review the most recent findings about how electrical activity shapes the developmental assembly of functional circuitry in the somatosensory cortex, with an emphasis on interneuron maturation and integration. We include studies on the effect of various neurotransmitters and on the influence of thalamocortical afferent activity on circuit development. We additionally reviewed studies describing network activity patterns. We conducted an extensive literature search using both the PubMed and Google Scholar search engines. The following keywords were used in various iterations: “interneuron”, “somatosensory”, “development”, “activity”, “network patterns”, “thalamocortical”, “NMDA receptor”, “plasticity”. We additionally selected papers known to us from past reading, and those recommended to us by reviewers and members of our lab. We reviewed a total of 132 articles that focused on the role of activity in interneuronal migration, maturation, and circuit development, as well as the source of electrical inputs and patterns of cortical activity in the somatosensory cortex. 79 of these papers included in this timely review were written between 2007 and 2016. Neuronal activity shapes the developmental assembly of functional circuitry in the somatosensory cortical interneurons. This activity impacts nearly every aspect of development and acquisition of mature neuronal characteristics, and may contribute to changing phenotypes, altered transmitter expression, and plasticity in the adult. Progressively changing oscillatory network patterns contribute to this activity in the early postnatal period, although a direct requirement for specific patterns and origins of activity remains to be demonstrated.