Duodenal gangliocytic paraganglioma, a rare entity among GEP-NET: a case report with immunohistochemical and molecular study.
Duodenal gangliocytic paraganglioma, a rare entity among GEP-NET: a case report with immunohistochemical and molecular study.
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DOI：
10.1186/1746-1596-9-54
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发表时间：
2014-03-12
影响因子：
2.6
通讯作者：
Botti, Gerardo
中科院分区：
文献类型：
--
作者：
Tatangelo, Fabiana;Cantile, Monica;Botti, Gerardo
胃肠胰腺神经内分泌肿瘤是最常见的神经内分泌肿瘤。在新的WHO分类（2010）中，每个肿瘤实体的胚胎学来源是最重要的参数之一。神经节细胞性副神经节瘤是一种起源于后肠的肿瘤，是一种罕见的肿瘤，通常累及十二指肠的第二部分，其中大多数是良性的。特别是，我们检查了一些神经内分泌标志物和神经元分化标志物NeuroD1的表达，其表达可以帮助更好地理解这种瘤形成的性质。虚拟幻灯片：本文的虚拟幻灯片可以在这里找到：http://www.diagnosticpathology.diagnomx.eu/vs/3720959161096807。
Gastroenteropancreatic neuroendocrine tumors are the most incident neuroendocrine tumors. In the new WHO classification (2010) the embryological derivation of each neoplastic entity is one of the most important parameters. Gangliocytic Paraganglioma is a tumor originating in the hindgut, a rare neoplasm, generally affecting the second portion of the duodenum, the majority of which are benign.Cases of gangliocytic paraganglioma with local metastasis or local recurrence have also been reported.We describe a GP in a 48-year-old caucasian male with an unusual site (4th portion of duodenum) and an interesting immunohistochemical and molecular pattern. In particular, we examined the expression of some neuroendocrine markers and a marker of neuronal differentiation, NeuroD1, whose expression can help to better understand the nature of this neoplasia.VIRTUAL SLIDES: The virtual slides for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/3720959161096807.