Human adipose dynamics and metabolic health.
Human adipose dynamics and metabolic health.
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DOI：
10.1111/nyas.12009
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发表时间：
2013-04
影响因子：
5.2
通讯作者：
Xu H
中科院分区：
文献类型：
--
作者：
Feng B;Zhang T;Xu H
人类的两种脂肪组织，白色和棕色，具有不同的发育起源和功能。人体白色脂肪组织在维持全身能量平衡方面起着关键作用，当能量过剩时，它储存甘油三酯，在能量不足时释放游离脂肪酸作为燃料，并分泌对调节脂质和葡萄糖代谢很重要的脂肪因子。白色脂肪团的大小需要保持在适当的设定点。白色脂肪量的急剧膨胀导致肥胖症现在已经成为一种全球性的流行病，并增加了许多危及生命的疾病的风险。缺乏白色脂肪组织或异常的白色脂肪组织再分布导致脂肪营养不良，这是一种通常与代谢紊乱相关的病症。棕色脂肪组织是一种产热器官，其质量与体重指数和年龄呈负相关。针对脂肪组织的治疗方法已被证明是有效的，在改善肥胖相关的代谢紊乱，并有前途的新疗法可以在不久的将来开发。
The two types of adipose tissue in humans, white and brown, have distinct developmental origins and functions. Human white adipose tissue plays a pivotal role in maintaining whole-body energy homeostasis by storing triglycerides when energy is in surplus, releasing free fatty acids as a fuel during energy shortage, and secreting adipokines that are important for regulating lipid and glucose metabolism. The size of white adipose mass needs to be kept at a proper set point. Dramatic expansion of white fat mass causes obesity—now become a global epidemic disease—and increases the risk for the development of many life-threatening diseases. The absence of white adipose tissue or abnormal white adipose tissue redistribution leads to lipodystrophy, a condition often associated with metabolic disorders. Brown adipose tissue is a thermogenic organ whose mass is inversely correlated with body mass index and age. Therapeutic approaches targeting adipose tissue have been proven to be effective in improving obesity-related metabolic disorders, and promising new therapies could be developed in the near future.