The Global Impact of Hepatic Fibrosis and End-Stage Liver Disease
The Global Impact of Hepatic Fibrosis and End-Stage Liver Disease
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DOI：
10.1016/j.cld.2008.07.007
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发表时间：
2008-11-01
影响因子：
5.1
通讯作者：
Kim, W. Ray
中科院分区：
文献类型：
--
作者：
Lim, Young-Suk;Kim, W. Ray
肝纤维化是慢性肝病发展过程中不可或缺的一部分，最终导致肝硬变和肝细胞癌。在全球范围内，饮酒、乙肝(乙肝)和丙型肝炎(丙型肝炎)一直是导致肝硬化的主要原因。最近，肥胖和代谢综合征的增加导致了继发于非酒精性脂肪性肝病(NAFLD)的肝硬变的发生率增加，特别是在发达国家。慢性肝病和肝硬变是世界范围内发病率和死亡率的重要原因。此外，慢性肝病的负担预计将增加，部分原因是终末期肝病和继发于非酒精性脂肪肝和丙型肝炎的肝细胞癌的患病率增加。
Hepatic fibrosis is an integral part in the progression of chronic liver disease, ultimately leading to cirrhosis and hepatocellular carcinoma. Globally, alcohol consumption, hepatitis B (HBV) and hepatitis C (HCV) have been the main causes of cirrhosis. More recently, the increasing prevalence of obesity and the metabolic syndrome has resulted in increasing incidence of cirrhosis secondary to nonalcoholic fatty liver disease (NAFLD), especially in developed countries. Chronic liver disease and cirrhosis are important causes of morbidity and mortality in the world. Moreover, the burden of chronic liver disease is projected to increase, due in part to the increasing prevalence of end-stage liver disease and HCC secondary to NAFLD and HCV.