Evaluation of a quantitative fetal fibronectin test for spontaneous preterm birth in symptomatic women
Evaluation of a quantitative fetal fibronectin test for spontaneous preterm birth in symptomatic women
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DOI：
10.1016/j.ajog.2012.10.890
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发表时间：
2013-02-01
影响因子：
9.8
通讯作者：
Shennan, Andrew H.
中科院分区：
文献类型：
--
作者：
Abbott, Danielle S.;Radford, Samara K.;Shennan, Andrew H.
目的：本研究的目的是确定是否量化宫颈阴道液胎儿纤维连接蛋白（fFN）提高诊断的准确性自发性早产（sPTB）在有症状的women.Study设计：前瞻性盲预定义的二次分析的宫颈阴道液fFN浓度的一项大型研究（纳克/毫升）在有早产症状的妇女（n =300名妇女;妊娠22-35周）中使用Hologic 10 Q系统（Hologic，马尔伯勒，MA）。临床医生在分娩前对结果不知情，但可获得定性的Hologic TLIIQ fFN结果。
OBJECTIVE: The purpose of this study was to determine whether quantification of cervicovaginal fluid fetal fibronectin (fFN) improves diagnostic accuracy of spontaneous preterm birth (sPTB) in symptomatic women.STUDY DESIGN: A prospective blinded predefined secondary analysis of a larger study of cervicovaginal fluid fFN concentration (nanograms per milliliter) in women symptomatic of preterm labor (n =300 women; 22-35 weeks' gestation) with a Hologic 10Q system (Hologic, Marlborough, MA). Clinicians were blinded to the result until after the delivery, but the qualitative Hologic TLIIQ fFN result was made available.RESULTS: The positive predictive value for sPTB (