Antibodies to myelin basic protein are associated with cognitive decline after stroke.
Antibodies to myelin basic protein are associated with cognitive decline after stroke.
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DOI：
10.1016/j.jneuroim.2016.04.001
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发表时间：
2016-06-15
影响因子：
3.3
通讯作者：
Buckwalter MS
中科院分区：
文献类型：
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作者：
Becker KJ;Tanzi P;Zierath D;Buckwalter MS
B淋巴细胞导致小鼠中风后认知能力下降。因此，我们在前瞻性收集的人类队列中评估了自身抗体与中风后认知能力下降之间的关系。卒中后30,90,180和365天分别进行简易精神状态检查（MMSE）。测定髓鞘碱性蛋白（MBP）、蛋白脂质蛋白和几种非特异性蛋白的抗体滴度。在58例卒中后一年内初始MMSE≥20且至少2次MMSE检查的受试者中，有10例（17%）受试者出现认知能力下降（MMSE下降≥2）。在多变量分析中，MBP抗体滴度是认知能力下降的唯一独立预测因子（OR=9.02 [1.18, 68.90]； P=0.03）。
B lymphocytes cause post-stroke cognitive decline in mice. We therefore evaluated the association between autoantibodies and post-stroke cognitive decline in a prospectively collected human cohort. The mini-mental state exam (MMSE) was administered 30, 90, 180, and 365 days after stroke. Antibody titers to myelin basic protein (MBP), proteolipid protein, and several non-specific proteins were determined. Among 58 subjects with initial MMSE≥20 and at least 2 MMSE examinations in the year after stroke, cognitive decline (MMSE decrease ≥2) occurred in 10 (17%) subjects. In multivariate analysis, MBP antibody titers were the only independent predictor of cognitive decline (OR=9.02 [1.18, 68.90]; P=0.03).