ELEVATED IMMUNOREACTIVE ENDOTHELIN-1 LEVELS IN NEWBORN-INFANTS WITH PERSISTENT PULMONARY-HYPERTENSION
ELEVATED IMMUNOREACTIVE ENDOTHELIN-1 LEVELS IN NEWBORN-INFANTS WITH PERSISTENT PULMONARY-HYPERTENSION
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DOI：
10.1016/s0022-3476(05)81552-5
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发表时间：
1993-07-01
影响因子：
5.1
通讯作者：
ABMAN, SH
中科院分区：
文献类型：
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作者：
ROSENBERG, AA;KENNAUGH, J;ABMAN, SH
为了研究内皮素-1（一种有效的内皮源性血管收缩肽）在新生儿持续性肺动脉高压 (PPHN) 病理生理学中的潜在作用，我们测量了 24 名患有 PPHN 的新生儿的免疫反应性内皮素-1 (irET-1) 的动脉浓度。次要诊断包括胎粪吸入综合征（13 例）、败血症（2 例）、先天性膈疝（1 例）、窒息（1 例）、肺出血（1 例）、误吸血液（1 例）和呼吸窘迫综合征（1 例）。与正常婴儿脐带血中的 irET-1 水平（15.1 +/- 4.1 pg/ml；平均值 +/- SEM）和机械通气支持的患有透明膜疾病的新生儿（11.8 +/- 1.2 pg/ml）相比，患有 PPHN 的婴儿的循环 irET-1 水平显着升高（27.6 +/- 3.6 pg/ml；p
To study the potential role of endothelin-1, a potent endothelium-derived vasoconstrictor peptide, in the pathophysiology of persistent pulmonary hypertension of the newborn (PPHN), we measured arterial concentrations of immunoreactive endothelin-1 (irET-1) in 24 neonates with PPHN. Secondary diagnoses included meconium aspiration syndrome (13 patients), sepsis (2), congenital diaphragmatic hernia (1), asphyxia (1), pulmonary hemorrhage (1), aspiration of blood (1), and respiratory distress syndrome (1). Compared with irET-1 levels in umbilical cord blood in normal infants (15.1 +/- 4.1 pg/ml; mean +/- SEM) and in newborn infants with hyaline membrane disease who were supported by mechanical ventilation (11.8 +/- 1.2 pg/ml), infants with PPHN had markedly elevated circulating irET-1 levels (27.6 +/- 3.6 pg/ml; p