THE ROLE OF MEMBRANE BIOPHYSICAL PROPERTIES IN THE REGULATION OF PROTEIN-KINASE-C ACTIVITY
THE ROLE OF MEMBRANE BIOPHYSICAL PROPERTIES IN THE REGULATION OF PROTEIN-KINASE-C ACTIVITY
复制标题
DOI：
10.1016/0165-6147(90)90234-y
复制
发表时间：
1990-08-01
影响因子：
13.8
通讯作者：
LESTER, DS
中科院分区：
文献类型：
--
作者：
EPAND, RM;LESTER, DS
在生理条件下，蛋白激酶C在与膜结合时具有活性。与大多数膜结合酶一样，其活性取决于其脂质环境的性质。在这篇文章中，Richard Epand和DavidLester描述了特定膜活性剂改变脂质环境的生物物理特性的能力与其调节蛋白激酶C活性的潜力之间的关系。他们认为，这可以通过调节膜的大量生物物理性质来更好地理解蛋白激酶C的抑制和激活机制，并可能为开发更特异性的抑制剂提供新的方法。
Under physiological conditions, protein kinase C is active when bound to membranes. Like most membrane-bound enzymes, its activity is dependent on the nature of its lipid environment. In this article,Richard Epand and DavidLester describe the relationship between the ability of specific membraneactive agents to alter the biophysical properties of the lipid environment and their potential to modulate protein kinase C activity. They argue that this can lead to a greater understanding of the mechanism of inhibition and activation of protein kinase C through modulation of the bulk biophysical properties of the membrane, and may provide a new approach to the development of a more specific set of inhibitors.