Effect of live attenuated, cold recombinant (CR) influenza virus vaccines on pulmonary function in healthy and asthmatic adults.
Effect of live attenuated, cold recombinant (CR) influenza virus vaccines on pulmonary function in healthy and asthmatic adults.
复制标题
减毒冷重组（CR）流感病毒活疫苗对健康成人和哮喘成人肺功能的影响。
DOI：
10.1016/0264-410x(90)90049-r
复制
发表时间：
1990
期刊：
影响因子：
5.5
通讯作者：
Greenberg,SB
中科院分区：
文献类型：
--
作者：
Atmar,RL;Bloom,K;Keitel,W;Couch,RB;Greenberg,SB
在安慰剂对照、双盲研究中，鼻腔接种CR流感病毒减毒活疫苗对健康成人和哮喘成人肺功能的影响进行了评估。在46名健康的成年志愿者中，在接种单价CR流感病毒疫苗[A型(H3N2，H1N1)和B型]后的第一周，通过肺活量测定和组胺支气管激发试验，肺功能没有显著变化。在接种前接种PC20s和lt；10mgml−-1的健康成人中，接种后有812例感染，但组胺支气管刺激反应未见明显变化。在11名成人哮喘患者中，在接种A型双价CR流感病毒疫苗(H3N2和H1N1)后的头7天内，通过肺活量测定，没有发现有统计学意义的肺功能变化。接种后呼吸道疾病在CR流感病毒疫苗接受者中比安慰剂接受者更常见，但它们是轻微的，包括发烧的咽炎和一过性鼻漏。在健康成人和哮喘成人免疫后的第一周，减毒的CR流感病毒疫苗似乎不会损害肺功能。
The effects of intranasal inoculation with live attenuated, CR influenza virus vaccines on pulmonary function in healthy and asthmatic adults were evaluated in placebo-controlled, double-blind studies. In 46 healthy adult volunteers, there were no statistically significant alterations in pulmonary function as measured by spirometry and histamine bronchoprovocation tests in the first week following monovalent CR influenza virus vaccine [type A (H3N2, H1N1) and type B]. Among healthy adults with pre-inoculation PC 20s< 10 mgml− 1, 8 12 were infected following vaccination but no significant alterations occurred in histamine bronchoprovocation. In 11 asthmatic adults, no statistically significant alterations in pulmonary function, as measured by spirometry, were noted during the first 7 days postinoculation with bivalent CR influenza virus vaccine type A (H3N2 and H1N1). Postinoculation respiratory illnesses were more common in CR influenza virus vaccine recipients than placebo recipients, but they were mild, consisting of a febrile pharyngitis and transient rhinorrhea. Attenuated CR influenza virus vaccines do not appear to impair pulmonary function during the first week following immunization of healthy and asthmatic adults.