The effects of learning about one's own genetic susceptibility to alcoholism: a randomized experiment
The effects of learning about one's own genetic susceptibility to alcoholism: a randomized experiment
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DOI：
10.1038/gim.2012.111
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发表时间：
2013-02-01
影响因子：
8.8
通讯作者：
Duberstein, Paul R.
中科院分区：
文献类型：
--
作者：
Dar-Nimrod, Ilan;Zuckerman, Miron;Duberstein, Paul R.
目的：越来越多的直接面向消费者的个性化基因报告提出了一个问题：人们如何受到关于他们自己遗传倾向的信息的影响？方法：参与者被引导相信他们已经进入了一项关于酒精中毒和睡眠障碍的遗传学研究。参与者提供了唾液样本，据称是为了检测相关基因的存在。在等待结果的同时，他们完成了一份评估自己情绪状态的问卷。他们随后收到了一份关于他们的遗传易感性的虚假报告，并完成了一份关于他们的情绪状态和项目的问卷，这些项目评估了他们对饮酒的控制感，相关的未来饮酒意图，以及与干预相关的动机和行为。结果：被引导相信自己携带与酒精中毒相关的基因的受试者，负面情绪增加，积极情绪减少，对饮酒的个人控制感降低。报告的近期饮酒意向没有受到影响；然而，在了解到他们所谓的遗传易感性后，个人更有可能参加“负责任的饮酒”研讨会。结论：第一个完全随机的实验，检查了接受个性化遗传易感性信息对心理和行为的影响，表明了直接面向消费者的基因测试的一些潜在的危险和好处。Genet Med 2013：15(2)：132-138
Purpose: Increased accessibility of direct-to-consumer personalized genetic reports raises the question: how are people affected by information about their own genetic predispositions?Methods: Participants were led to believe that they had entered a study on the genetics of alcoholism and sleep disorders. Participants provided a saliva sample purportedly to be tested for the presence of relevant genes. While awaiting the results, they completed a questionnaire assessing their emotional state. They subsequently received a bogus report about their genetic susceptibility and completed a questionnaire about their emotional state and items assessing perceived control over drinking, relevant future drinking-related intentions, and intervention-related motivation and behavior.Results: Participants who were led to believe that they had a gene associated with alcoholism showed an increase in negative affect, decrease in positive affect, and reduced perceived personal control over drinking. Reported intentions for alcohol consumption in the near future were not affected; however, individuals were more likely to enroll in a "responsible drinking" workshop after learning of their alleged genetic susceptibility.Conclusion: The first complete randomized experiment to examine the psychological and behavioral effects of receiving personalized genetic susceptibility information indicates some potential perils and benefits of direct-to-consumer genetic tests. Genet Med 2013:15(2):132-138