Magnetic Susceptibility Difference-Induced Nucleus Positioning in Gradient Ultrahigh Magnetic Field
Magnetic Susceptibility Difference-Induced Nucleus Positioning in Gradient Ultrahigh Magnetic Field
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DOI：
10.1016/j.bpj.2019.12.020
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发表时间：
2019-12
影响因子：
3.4
通讯作者：
Qingping Tao;Lei Zhang;Xuyao Han;Hanxiao Chen;Xinmiao Ji;Xin Zhang
中科院分区：
文献类型：
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作者：
Qingping Tao;Lei Zhang;Xuyao Han;Hanxiao Chen;Xinmiao Ji;Xin Zhang
尽管生物样品的磁性对生物磁学和相关领域具有重要意义，但大多数生物样品在其生理条件下的确切磁化率仍然是未知的。在37℃（310 K）的生理温度下，我们使用超导量子干干仪装置检测了非固定、非脱水活细胞和细胞组分的磁性。可见，人鼻咽癌CNE-2Z细胞中存在顺磁成分。更重要的是，细胞质和细胞核的磁性是不同的。虽然在单个细胞内，细胞部分（细胞核和细胞质）之间的磁化率差异只能在13.1-23.5 T （92-160 T/m）的梯度超高磁场下对细胞核产生~ 41-130 pN力，但这些力足以导致细胞核在细胞内的相对位置移动。这不仅说明了磁化率在磁场生物效应中的重要性，也说明了高磁场在生物医学中的潜在应用。
Despite the importance of magnetic properties of biological samples for biomagnetism and related fields, the exact magnetic susceptibilities of most biological samples in their physiological conditions are still unknown. Here we used superconducting quantum interferometer device to detect the magnetic properties of nonfixed, nondehydrated live cell and cellular fractions at a physiological temperature of 37°C (310 K). It is obvious that there are paramagnetic components within human nasopharyngeal carcinoma CNE-2Z cells. More importantly, the magnetic properties of the cytoplasm and nucleus are different. Although within a single cell, the magnetic susceptibility difference between cellular fractions (nucleus and cytoplasm) could only cause ∼41–130 pN forces to the nucleus by gradient ultrahigh magnetic fields of 13.1–23.5 T (92–160 T/m), these forces are enough to cause a relative position shift of the nucleus within the cell. This not only demonstrates the importance of magnetic susceptibility in the biological effects of magnetic field but also illustrates the potential application of high magnetic fields in biomedicine.