The School Inner-City Asthma Study: Design, Methods, and Lessons Learned
The School Inner-City Asthma Study: Design, Methods, and Lessons Learned
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DOI：
10.3109/02770903.2011.624235
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发表时间：
2011-12-01
影响因子：
1.9
通讯作者：
Gold, Diane R.
中科院分区：
文献类型：
--
作者：
Phipatanakul, Wanda;Bailey, Anne;Gold, Diane R.
背景孩子们在学校花了大量的时间。关于过敏原暴露在学校环境和哮喘发病率中的作用知之甚少。目标.学校内城哮喘研究（SICAS）是一项由美国国立卫生研究院（NIH）资助的前瞻性研究，旨在评估城市儿童中学校/教室特定的风险因素和哮喘发病率。方法/结果。本文介绍了设计，方法和重要的经验教训，从这个广泛的调查。一个中心正在招募500名小学适龄儿童，他们都在市中心的大都市学校上学。主要假设是，即使在控制了家庭过敏原暴露后，教室中常见的室内过敏原暴露也会增加哮喘儿童的哮喘发病率。该方案包括对整个学校的筛选调查和学年前春季获得的基线资格评估。在学年前的夏季，正在对符合条件的哮喘儿童进行广泛的基线临床访视。环境教室/学校评估，包括沉降灰尘和空气采样过敏原，霉菌，空气污染和检查数据收集两次在学年和一个家庭灰尘样本与注册的学生。临床结果在学年期间每3个月测量一次。结论SICAS的总体目标是完成第一项同类研究，以更好地了解学校特定的城市环境因素对儿童哮喘发病率的影响。我们还讨论了与以学校为基础的城市研究相关的独特挑战，以及从招募这样一个群体中吸取的经验教训。
Background. Children spend a significant amount of time in school. Little is known about the role of allergen exposure in school environments and asthma morbidity. Objectives. The School Inner-City Asthma Study (SICAS) is a National Institutes of Health (NIH)-funded prospective study evaluating the school/classroom-specific risk factors and asthma morbidity among urban children. Methods/results. This article describes the design, methods, and important lessons learned from this extensive investigation. A single center is recruiting 500 elementary school-aged children, all of whom attend inner-city metropolitan schools. The primary hypothesis is that exposure to common indoor allergens in the classroom will increase the risk of asthma morbidity in children with asthma, even after controlling for home allergen exposures. The protocol includes screening surveys of entire schools and baseline eligibility assessments obtained in the spring prior to the academic year. Extensive baseline clinical visits are being conducted among eligible children with asthma during the summer prior to the academic school year. Environmental classroom/school assessments including settled dust and air sampling for allergen, mold, air pollution, and inspection data are collected twice during the academic school year and one home dust sample linked to the enrolled student. Clinical outcomes are measured every 3 months during the academic school year. Conclusion. The overall goal of SICAS is to complete the first study of its kind to better understand school-specific urban environmental factors on childhood asthma morbidity. We also discuss the unique challenges related to school-based urban research and lessons being learned from recruiting such a cohort.