Nickel(0)-catalyzed intramolecular reductive coupling of alkenes and aldehydes or ketones with hydrosilanes
Nickel(0)-catalyzed intramolecular reductive coupling of alkenes and aldehydes or ketones with hydrosilanes
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DOI：
10.1039/c6cc01915c
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发表时间：
2016-01-01
影响因子：
4.9
通讯作者：
Ogoshi, Sensuke
中科院分区：
文献类型：
--
作者：
Hayashi, Yukari;Hoshimoto, Yoichi;Ogoshi, Sensuke
A nickel(0)-catalyzed reductive coupling of aldehydes and simple alkenes with hydrosilanes has been developed. A variety of silyl-protected 1-indanol derivatives were prepared in a highly diastereo-selective manner (up to >99:1 dr) by employing a combination of nickel(0)/N-heterocyclic carbene and triethylsilane. The present system was also applied to a reductive coupling with ketones. Preliminary results of a nickel(0)-catalyzed asymmetric three-component coupling reaction of an aldehyde, an alkene, and triethylsilane are also shown.
