Genome-wide transcriptomic alterations induced by ethanol treatment in human dental pulp stem cells (DPSCs).
Genome-wide transcriptomic alterations induced by ethanol treatment in human dental pulp stem cells (DPSCs).
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DOI：
10.1016/j.gdata.2014.06.011
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发表时间：
2014-12-01
期刊：
影响因子：
--
通讯作者：
Kim, Yong
中科院分区：
文献类型：
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作者：
Khalid, Omar;Kim, Jeffrey J;Duan, Lewei;Hoang, Michael;Elashoff, David;Kim, Yong
人牙髓干细胞（DPSC）是从成人牙髓中分离的多能间充质干细胞，其可定向分化为成骨/牙源性细胞，也可转分化为神经元细胞。DPSC在牙源性分化和牙齿再生中的应用已被探索。酗酒似乎会导致牙周病、蛀牙和口腔溃疡，这些都是潜在的癌前病变。酗酒者的牙齿、牙龈和口腔健康普遍严重恶化的风险很高。目前尚不清楚酒精暴露是否对成体干细胞维持、干细胞命运决定和可塑性以及干细胞生态位环境有任何影响。在这里，我们提供了详细的实验方法，分析和信息与我们的数据存入基因表达综合（GEO）下GSE 57255。我们的数据提供了在24小时和48小时时间点通过EtOH处理DPSC发生的转录组学变化。
Human dental pulp stem cells (DPSCs) isolated from adult dental pulp are multipotent mesenchymal stem cells that can be directed to differentiate into osteogenic/odontogenic cells and also trans-differentiate into neuronal cells. The utility of DPSC has been explored in odontogenic differentiation for tooth regeneration. Alcohol abuse appears to lead to periodontal disease, tooth decay and mouth sores that are potentially precancerous. Persons who abuse alcohol are at high risk of having seriously deteriorated teeth, gums and compromised oral health in general. It is currently unknown if alcohol exposure has any impact on adult stem cell maintenance, stem cell fate determination and plasticity, and stem cell niche environment. Here we provide detailed experimental methods, analysis and information associated with our data deposited into Gene Expression Omnibus (GEO) under GSE57255. Our data provide transcriptomic changes that are occurring by EtOH treatment of DPSCs at 24-hour and 48-hour time point.