Neurotrophin treatment to promote regeneration after traumatic CNS injury.
Neurotrophin treatment to promote regeneration after traumatic CNS injury.
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DOI：
10.1007/s11515-013-1269-8
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发表时间：
2013-10-01
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神经营养因子是一个生长因子家族，已发现其对于神经系统的发育和功能维持是重要的，参与神经发生、神经元存活、轴突生长、突触发生和突触可塑性的活性依赖性形式。成人神经系统的创伤可破坏神经元的功能回路并导致严重的功能缺陷。成人神经系统内在生长能力的限制和恶劣环境的存在是受损成人神经元轴突再生的主要障碍。神经营养因子已被证明是介导神经元修复和通过激活包括神经元内在再生程序在内的几种生长信号机制建立功能回路的优秀候选物。在这里，我们将审查各种神经营养因子在介导成人脊髓损伤后恢复的影响。
Neurotrophins are a family of growth factors that have been found to be central for the development and functional maintenance of the nervous system, participating in neurogenesis, neuronal survival, axonal growth, synaptogenesis and activity-dependent forms of synaptic plasticity. Trauma in the adult nervous system can disrupt the functional circuitry of neurons and result in severe functional deficits. The limitation of intrinsic growth capacity of adult nervous system and the presence of an inhospitable environment are the major hurdles for axonal regeneration of lesioned adult neurons. Neurotrophic factors have been shown to be excellent candidates in mediating neuronal repair and establishing functional circuitry via activating several growth signaling mechanisms including neuron-intrinsic regenerative programs. Here, we will review the effects of various neurotrophins in mediating recovery after injury to the adult spinal cord.