Hydrogel Functionalized Janus Membrane for Skin Regeneration
Hydrogel Functionalized Janus Membrane for Skin Regeneration
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DOI：
10.1002/adhm.201600795
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发表时间：
2017-03-08
影响因子：
10
通讯作者：
Hwang, Nathaniel S.
中科院分区：
文献类型：
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作者：
An, Young-Hyeon;Yu, Seung Jung;Hwang, Nathaniel S.
在这项研究中，水凝胶功能化的Janus膜的开发和其能力作为伤口敷料生物材料进行了检查。通过引发化学气相沉积法将疏水性含氟聚合物聚甲基丙烯酸3，3，4，4，5，5，6，6，7，7，8，8，9，9，10，10，10-十七碳十二烷基酯（PHFDMA）均匀地涂覆在大孔聚酯膜的两面。PHFDMA涂层大孔膜具有抗菌性能，允许空气渗透，并抑制水渗透。Janus膜性质通过将PHFDMA涂覆的膜的一侧暴露于IM KOH溶液获得，这允许PHFDMA裂解，从而产生羧酸残基。该羧酸残基然后进一步用基于明胶甲基丙烯酸酯的可光交联水凝胶官能化，用于保湿和生长因子释放。当应用于全厚度背部皮肤缺损模型时，功能化水凝胶允许保湿，并且疏水表面通过防水性防止渗出物泄漏。此外，水凝胶功能化的Janus膜提高了伤口愈合速率并诱导厚的表皮层形成。总之，具有疏水外表面和在另一表面上的固定化水凝胶的多功能Janus膜被制造用于伤口愈合的创新策略。
In this study, a hydrogel functionalized Janus membrane is developed and its capacity is examined as a wound dressing biomaterial. A hydrophobic fluoropolymer, poly(3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodecyl methacrylate) (PHFDMA), is uniformly coated onto macroporous polyester membrane through initiated chemical vapor deposition process on both sides. PHFDMA-coated macroporous membrane exhibits antibacterial property, allows air permeation, and inhibits water penetration. Janus membrane property is obtained by exposing one side of PHFDMA coated membrane with 1 m KOH solution, which allows PHFDMA cleavage resulting in carboxylic acid residue. This carboxylic acid residue is then further functionalized with gelatin methacrylate-based photocrosslinkable hydrogel for moisture retention and growth factor release. When applied to full thickness dorsal skin defect model, functionalized hydrogel allows moisture retention and hydrophobic surface prevents exudate leaks via water repellence. Furthermore, hydrogel functionalized Janus membrane enhances the wound healing rate and induces thick epidermal layer formation. In conclusion, the multifunctional Janus membrane with hydrophobic outer surface and immobilized hydrogel on the other surface is fabricated for an innovative strategy for wound healing.