Effects of Resveratrol on Memory Performance, Hippocampal Functional Connectivity, and Glucose Metabolism in Healthy Older Adults
Effects of Resveratrol on Memory Performance, Hippocampal Functional Connectivity, and Glucose Metabolism in Healthy Older Adults
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DOI：
10.1523/jneurosci.0385-14.2014
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发表时间：
2014-06-04
影响因子：
5.3
通讯作者：
Floeel, Agnes
中科院分区：
文献类型：
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作者：
Witte, A. Veronica;Kerti, Lucia;Floeel, Agnes
限制热量或模仿这些效果的营养物质等饮食习惯可能对大脑衰老产生有益的影响。植物来源的多酚白藜芦醇已被证明可以提高灵长类动物的记忆能力；然而，缺乏针对老年人的干预研究。在这里，我们测试了补充白藜芦醇是否会增强老年人的记忆力，并探讨了这种效应背后的潜在机制。成功完成 26 周白藜芦醇摄入（200 毫克/天）的 23 名健康超重老年人与接受安慰剂的 23 名参与者进行配对（总共 n = 46，其中 18 名女性，50-75 岁）。在干预/控制期之前和之后，受试者接受了记忆任务和神经影像学检查，以评估海马体的体积、微观结构和功能连接（FC），海马体是与记忆功能有关的关键区域。此外，还检测了人体测量、葡萄糖和脂质代谢、炎症、神经营养因子和血管参数。我们观察到，与安慰剂相比，白藜芦醇对 30 分钟以上的单词记忆有显着影响（p = 0.038）。此外，与安慰剂相比，白藜芦醇导致海马 FC 显着增加，糖化血红蛋白 (HbA1c) 和体脂减少，瘦素增加（所有 p < 0.05）。左后海马和内侧前额皮质之间 FC 的增加与保留分数的增加和 HbA1c 的降低相关（所有 p < 0.05）。这项研究提供了初步证据，表明补充白藜芦醇可改善老年人的记忆力，这与改善葡萄糖代谢和增加海马 FC 相关。我们的研究结果为在衰老过程中维持大脑健康的新策略提供了基础。
Dietary habits such as caloric restriction or nutrients that mimic these effects may exert beneficial effects on brain aging. The plant-derived polyphenol resveratrol has been shown to increase memory performance in primates; however, interventional studies in older humans are lacking. Here, we tested whether supplementation of resveratrol would enhance memory performance in older adults and addressed potential mechanisms underlying this effect. Twenty-three healthy overweight older individuals that successfully completed 26 weeks of resveratrol intake (200 mg/d) were pairwise matched to 23 participants that received placebo (total n = 46, 18 females, 50-75 years). Before and after the intervention/control period, subjects underwent memory tasks and neuroimaging to assess volume, microstructure, and functional connectivity (FC) of the hippocampus, a key region implicated in memory functions. In addition, anthropometry, glucose and lipid metabolism, inflammation, neurotrophic factors, and vascular parameters were assayed. We observed a significant effect of resveratrol on retention of words over 30 min compared with placebo (p = 0.038). In addition, resveratrol led to significant increases in hippocampal FC, decreases in glycated hemoglobin (HbA1c) and body fat, and increases in leptin compared with placebo (all p < 0.05). Increases in FC between the left posterior hippocampus and the medial prefrontal cortex correlated with increases in retention scores and with decreases in HbA1c (all p < 0.05). This study provides initial evidence that supplementary resveratrol improves memory performance in association with improved glucose metabolism and increased hippocampal FC in older adults. Our findings offer the basis for novel strategies to maintain brain health during aging.