Gastrointestinal symptoms in low-dose aspirin users: a comparison between plain and buffered aspirin
Gastrointestinal symptoms in low-dose aspirin users: a comparison between plain and buffered aspirin
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DOI：
10.1007/s12471-014-0522-3
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发表时间：
2014-03-01
影响因子：
2
通讯作者：
van Oijen, M. G. H.
中科院分区：
文献类型：
--
作者：
Focks, J. Jaspers;Tielemans, M. M.;van Oijen, M. G. H.
阿司匹林与胃肠道副作用有关，如胃溃疡、胃出血和消化不良。在健康志愿者中，与普通阿司匹林相比，高剂量的卡巴氨酸钙（ECC），一种阿司匹林的缓冲制剂，与胃毒性降低有关，但在较低的心血管剂量下，没有观察到有益的效果。2008年12月，向荷兰成年普通人群的代表性样本发送了869份问卷。对人口统计学、胃肠道症状（一般和特殊症状）、合并症和药物使用（包括生物等效剂量的ECC（100 mg）和普通阿司匹林（80 mg））等问题进行了说明。我们采用单因素和多因素logistic回归分析，调查了ECC与普通阿司匹林相比，自我报告的胃肠道症状的患病率，共收回16，715份问卷（32%），并进行了分析。其中，911名（5%）受访者报告使用普通阿司匹林，633名（4%）ECC和15，171名（91%）报告使用任何形式的阿司匹林。总体而言，使用ECC的受访者（27.5%）自我报告的胃肠道症状的患病率高于普通阿司匹林（26.3%），但单变量（OR 1.06，95% CI 0.84-1.33）或多变量分析（aOR 1.08，95% CI 0.83-1.41）无显著差异。此外，两种阿司匹林制剂之间的具体症状类型无差异。在这个代表荷兰一般人群的大型队列中，与普通阿司匹林相比，低剂量ECC与自我报告的胃肠道症状减少无关。
Aspirin is associated with gastrointestinal side effects such as gastric ulcers, gastric bleeding and dyspepsia. High-dose effervescent calcium carbasalate (ECC), a buffered formulation of aspirin, is associated with reduced gastric toxicity compared with plain aspirin in healthy volunteers, but at lower cardiovascular doses no beneficial effects were observed.To compare the prevalence of self-reported gastrointestinal symptoms between low-dose plain aspirin and ECC.A total of 51,869 questionnaires were sent to a representative sample of the Dutch adult general population in December 2008. Questions about demographics, gastrointestinal symptoms in general and specific symptoms, comorbidity, and medication use including bioequivalent doses of ECC (100 mg) and plain aspirin (80 mg) were stated. We investigated the prevalence of self-reported gastrointestinal symptoms on ECC compared with plain aspirin using univariate and multivariate logistic regression analyses.A total of 16,715 questionnaires (32 %) were returned and eligible for analysis. Of these, 911 (5 %) respondents reported the use of plain aspirin, 633 (4 %) ECC and 15,171 reported using neither form of aspirin (91 %). The prevalence of self-reported gastrointestinal symptoms in general was higher in respondents using ECC (27.5 %) compared with plain aspirin (26.3 %), but did not differ significantly with either univariate (OR 1.06, 95 %CI 0.84-1.33), or multivariate analysis (aOR 1.08, 95 %CI 0.83-1.41). Also, none of the specific types of symptoms differed between the two aspirin formulations.In this large cohort representative of the general Dutch population, low-dose ECC is not associated with a reduction in self-reported gastrointestinal symptoms compared with plain aspirin.