The genetic relationship between epilepsy and hemiplegic migraine.
The genetic relationship between epilepsy and hemiplegic migraine.
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癫痫与偏瘫性偏头痛的遗传关系
DOI：
10.2147/ndt.s132451
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发表时间：
2017
影响因子：
3.2
通讯作者：
Wu Y
中科院分区：
文献类型：
--
作者：
Huang Y;Xiao H;Qin X;Nong Y;Zou D;Wu Y
癫痫和偏头痛是常见的神经系统疾病，具有共同的遗传和病理生理机制。家族性偏瘫性偏头痛是一种常染色体显性遗传病。它经常被用作偏头痛的模型。在癫痫和偏瘫偏头痛患者中，有四个基因通常包含一个或多个突变（即CACNA1A、ATP1A2、SCN1A和PRRT2）。更好地了解癫痫和偏瘫性偏头痛的共同遗传学可能为这两种疾病的研究和治疗揭示新的战略方向。
Epilepsy and migraine are common diseases of the nervous system and share genetic and pathophysiological mechanisms. Familial hemiplegic migraine is an autosomal dominant disease. It is often used as a model of migraine. Four genes often contain one or more mutations in both epilepsy and hemiplegic migraine patients (ie, CACNA1A, ATP1A2, SCN1A, and PRRT2). A better understanding of the shared genetics of epilepsy and hemiplegic migraine may reveal new strategic directions for research and treatment of both the disorders.