Chloral hydrate toxicity in a preterm infant.
Chloral hydrate toxicity in a preterm infant.
复制标题
水合氯醛对早产儿的毒性。
DOI：
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发表时间：
1984
期刊：
影响因子：
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通讯作者：
Charles R. Rosenfeld
中科院分区：
文献类型：
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作者：
A. Laptook;Charles R. Rosenfeld
患有肺透明膜病（HMD）的早产儿的呼吸机护理可能会因易怒和“对抗”呼吸机而变得复杂，从而导致严重的低氧血症。常用药物（如泮库溴铵）进行神经肌肉阻滞，以控制该问题[Crone和Favorito，1980]。这种治疗会导致重要的临床体征丧失，例如肌张力和自发运动的改变，这对于监测危重新生儿非常重要。由于这些考虑，我们偶尔会使用水合氯醛的镇静催眠作用来使这些婴儿获得足够的通气和氧合。然而，我们报告了一例早产儿在服用水合氯醛作为HMD治疗的辅助治疗后出现严重毒性的病例。
Ventilator care in premature infants with hyaline membrane disease (HMD) may be complicated by episodes of irritability and "fighting" the respirator, resulting in significant hypoxemia. Neuromuscular blockade with pharmacologic agents such as pancuronium bromide is frequently used to manage this problem [Crone and Favorito, 1980]. This therapy results in the loss of important clinical signs, such as alterations in muscle tone and spontaneous movements, which are important in monitoring the critically ill newborn. As a result of these considerations, we occasionally have utilized the sedative-hypnotic effects of chloral hydrate to achieve adequate ventilation and oxygenation in these infants. We report, however, a case of a preterm infant who developed severe chloral hydrate toxicity after its administration as an adjunct to the treatment of HMD.