JBIR-129 and -139, cytotoxic 34-membered polyol macrolides of microbial origin

JBIR-129 and -139, cytotoxic 34-membered polyol macrolides of microbial origin
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JBIR-129 和 -139，微生物来源的细胞毒性 34 元多元醇大环内酯

DOI：
10.1021/np3004358
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发表时间：
2012
期刊：
J. Nat. Prod
影响因子：
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通讯作者：
Motoki Takagi and Kazuo Shin-ya
Motoki Takagi and Kazuo Shin-ya
中科院分区：
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文献类型：
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作者：
Teppei Kawahara;Ji-Hwan Hwang;Miho Izumikawa;Junko Hashimoto;Motoki Takagi and Kazuo Shin-ya

文献摘要

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从陆地链霉菌RK 74的培养物中分离得到新的34元多羟基大环内酯JBIR-129（1）和JBIR-139（2）。通过1D和2D NMR、ESI-TOF-MS、IR和UV光谱确定了化合物1和2的平面结构。通过分析邻位1H-1H偶合常数和空间位阻信息确定了糖单元的相对构型。化合物1和化合物2对人卵巢癌SKOV-3细胞具有较强的细胞毒活性，IC 50值分别为0.3和0.4 μM。
New 34-membered polyol macrolides JBIR-129 (1) and JBIR-139 (2) were isolated from the culture of the terrestrialStreptomycesRK74. The planar structures of1and2were established on the basis of 1D and 2D NMR, ESI-TOF-MS, IR, and UV spectra. The relative configurations of the sugar units were determined by analyzing vicinal1H–1H coupling constants and steric information. Both1and2showed cytotoxic activity against human ovarian adenocarcinoma SKOV-3 cells with IC50values of 0.3 and 0.4 μM, respectively.