Central Executive and Default Mode Network Intranet work Functional Connectivity Patterns in Chronic Migraine.
Central Executive and Default Mode Network Intranet work Functional Connectivity Patterns in Chronic Migraine.
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DOI：
10.4172/2329-6895.1000393
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发表时间：
2018-01-01
期刊：
影响因子：
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通讯作者：
Newman, Roger
中科院分区：
文献类型：
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作者：
Androulakis, X Michelle;Krebs, Kaitlin A;Newman, Roger
背景：慢性偏头痛的神经机制在很大程度上仍然未知，但与内在脑网络连通性下降有关。目的：研究伴有和不伴有药物过度使用性头痛（MOH）的慢性偏头痛（CM）患者中央执行网络（CEN）和默认模式网络（DMN）内网络功能连通性的特征。方法：利用功能性磁共振成像技术，我们对CM （n=13）和CMMOH （n=16）患者的CEN内共136对节点到节点功能连接（NTNC）和DMN内6对NTNC进行了事后分析，与对照组相比，以及这两个亚组之间。结果：CM和CMMOH亚组CEN内右腹外侧前额叶皮质（PFC）与对侧丘脑前部的连通性以及左背外侧前额叶皮质/额叶视野（FEF）与背内侧前额叶皮质的连通性均下降。在CEN中，与健康对照组相比，CMMOH （n=16）比CM （n=13）有更广泛的破坏。在亚组中，与CM相比，CMMOH的右额下回与左背外侧PFC之间的连通性降低。在DMN中，与对照组相比，CMMOH组只有一个NTNC（左外侧顶叶到楔前叶/PCC）被破坏。结论：与MOH状态无关，CM患者CEN内NTNC功能障碍模式相似。我们观察到CMMOH比CM更广泛的内部网络中断。在CMMOH中，右侧额下回和左背外侧PFC之间的一致性下降可能与抑制控制的显著破坏以及风险厌恶和奖励的适应不良反应有关；而右背外侧和腹外侧PFC与对侧背侧PFC/FEF之间一致性的降低可能与CM和CMMOH中缺乏认知控制和自上而下的疼痛调节有关。
BACKGROUND: The neural mechanisms of chronic migraine remain largely unknown but linked to the decreased connectivity to intrinsic brain networks.OBJECTIVE: To characterize the intranetwork functional connectivity within the Central Executive Network (CEN) and Default Mode Network (DMN) in chronic migraine (CM), with and without medication overuse headache (MOH).METHODS: Using functional magnetic resonance imaging, we performed post-hoc analysis of a total of 136 pairs of nodes to node functional connectivity (NTNC) within the CEN and 6 pairs of NTNC within the DMN in CM (n=13) and CMMOH (n=16) as compared to controls, and between these two subgroups.RESULTS: Connectivity between right ventrolateral prefrontal cortex (PFC) to contralateral anterior thalamus and connectivity between left dorsal PFC/frontal eye field (FEF) to dorsomedial PFC were decreased within the CEN in both CM and CMMOH subgroups. In the CEN, there was more widespread disruption in the CMMOH (n=16) versus CM (n=13), when compared to healthy controls. Within the subgroups, connectivity between right inferior frontal gyrus to left dorsolateral PFC was decreased in CMMOH compared to CM. In the DMN, only one NTNC (left lateral parietal to precuneus/PCC) was disrupted in the CMMOH group when compared to controls.CONCLUSION: There are similar patterns of NTNC dysfunction within CEN in CM regardless of MOH status. We observed more extensive intranetwork disruption in CMMOH than CM. The decreased coherence between the right inferior frontal gyrus and the left dorsolateral PFC in CMMOH is likely associated with a significant disruption in the inhibitory control and a maladaptive response in risk aversion and reward; whereas the decreased coherence between right dorsolateral and ventrolateral PFC to contralateral dorsal PFC/FEF may be related to lack of cognitive control and top-down regulation of pain in both CM and CMMOH.