Offline consolidation of memory varies with time in slow wave sleep and can be accelerated by cuing memory reactivations
Offline consolidation of memory varies with time in slow wave sleep and can be accelerated by cuing memory reactivations
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DOI：
10.1016/j.nlm.2012.07.002
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发表时间：
2012-09-01
影响因子：
2.7
通讯作者：
Born, Jan
中科院分区：
文献类型：
--
作者：
Diekelmann, Susanne;Biggel, Simon;Born, Jan
记忆表征在学习后的慢波睡眠（SWS）中被重新激活，这些重新激活导致睡眠对记忆巩固的有益影响。记忆再激活也可以在睡眠期间由相关的外部线索触发，从而增强依赖睡眠的记忆巩固过程。在这里，我们比较了人类睡眠时间(i) 40分钟和（ii） 90分钟没有外部触发的再激活和（iii）在40分钟睡眠期间由相关气味线索触发的外部触发的再激活对先前学习的海马体依赖的视觉空间记忆巩固的影响。我们发现，在40分钟的睡眠期间，气味线索的外部再激活与90分钟无气味再激活的睡眠相同，对记忆稳定性的增强程度相同。相比之下，没有外部再激活的40分钟睡眠不足以使记忆受益。在90分钟的睡眠条件下，记忆增强与静睡眠时间有关，与快速眼动睡眠的存在与否无关。这些结果表明，海马体依赖性记忆巩固的效果取决于睡眠的持续时间，特别是SWS。即使在较短的睡眠期间，外部再激活线索也能加速巩固过程。(C) 2012爱思唯尔公司版权所有。
Memory representations are reactivated during slow-wave sleep (SWS) after learning, and these reactivations cause a beneficial effect of sleep for memory consolidation. Memory reactivations can also be externally triggered during sleep by associated cues which enhance the sleep-dependent memory consolidation process. Here, we compared in humans the influence of sleep periods (i) of 40 min and (ii) of 90 min without externally triggered reactivations and (iii) of externally triggered reactivations by an associated odor cue during a 40-min sleep period on the consolidation of previously learned hippocampus-dependent visuo-spatial memories. We show that external reactivation by an odor cue during the 40-min sleep period enhanced memory stability to the same extent as 90 min of sleep without odor reactivation. In contrast, 40 min of sleep without external reactivations were not sufficient to benefit memory. In the 90-min sleep condition, memory enhancements were associated with time spent in SWS and were independent of the presence or absence of REM sleep. These results suggest that the efficacy of hippocampus-dependent memory consolidation depends on the duration of sleep and particularly SWS. External reactivation cues can accelerate the consolidation process even during shorter sleep episodes. (C) 2012 Elsevier Inc. All rights reserved.